Pharos : Target Details

Tbio

Protein Summary

Description

Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.

Uniprot Accession IDs

Gene Name

RPF2

Ensembl ID

ENST00000441448
ENSP00000402338
ENSG00000197498

Symbol

BXDC1
BXDC1
bA397G5.4

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91

kinase perturbation	0.88

hub protein	0.85

interacting protein	0.82

transcription factor binding site profile	0.69

Protein Classes

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.49 (req: < 5)

View Publications

Gene RIFs: 1 (req: <= 3)

View Gene RIFs

Antibodies: 155 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.49 (req: >= 5)

Gene RIFs: 1 (req: > 3)

Antibodies: 155 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (362)

Explore Interacting Targets

1 – 10 of 362

See Interactions on String-DB

CNBP

Tbio

Novelty: 0.00404247

p_int: 0.990495563

p_ni: 0.009504437

Score: 0.363

Data Source: BioPlex,STRINGDB

ZNF2

Tbio

Family: TF

Novelty: 0.01062543

p_int: 0.983312789

p_ni: 0.016687211

Data Source: BioPlex

RRS1

Tbio

Novelty: 0.01643671

p_int: 0.981206044

p_ni: 0.018793956

Score: 0.999

Data Source: BioPlex,STRINGDB

RBM4

Tbio

Novelty: 0.02034191

p_int: 0.980545034

p_ni: 0.019454966

Score: 0.166

Data Source: BioPlex,STRINGDB

NOP53

Tbio

Novelty: 0.00353077

p_int: 0.976233716

p_ni: 0.023766284

Score: 0.985

Data Source: BioPlex,STRINGDB

GPATCH4

Tdark

Novelty: 1.13040547

p_int: 0.972786931

p_ni: 0.027213068

Score: 0.759

Data Source: BioPlex,STRINGDB

RBM34

Tdark

Novelty: 0.58131282

p_int: 0.960129574

p_ni: 0.039870426

Score: 0.981

Data Source: BioPlex,STRINGDB

RRP8

Tbio

Family: Enzyme

Novelty: 0.04922797

p_int: 0.959561528

p_ni: 0.040438472

Score: 0.932

Data Source: BioPlex,STRINGDB

RPL37A

Tbio

Novelty: 0.03475061

p_int: 0.948296459

p_ni: 0.051703541

Score: 0.701

Data Source: BioPlex,STRINGDB

KNOP1

Tdark

Novelty: 0.5609503

p_int: 0.947382172

p_ni: 0.052617828

Score: 0.303

Data Source: BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (10)

Functions (3)

Components (2)

Processes (5)

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1 – 3 of 3

GO Term	Evidence	Assigned by
5S rRNA binding	Inferred from Direct Assay (IDA)	UniProtKB

RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

rRNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (2)

Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Evidence (Mean Rank Score)
blood metabolite measurement	EFO_0005664	2	1	2	59.8

amino acid measurement	EFO_0005134	1	1	1	42.3

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Evidence (Mean Rank Score)
blood metabolite measurement	EFO_0005664	2	59.8

amino acid measurement	EFO_0005134	1	42.3

Beta Count

Odds Ratio

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UniProt Keyword

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GWAS Trait

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IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID
Chimp	ribosome production factor 2 homolog	VGNC:11215	462940

Macaque	ribosome production factor 2 homolog		696378

Mouse	ribosome production factor 2 homolog	MGI:1914489	67239

Rat	ribosome production factor 2 homolog	RGD:1306906	294436

Dog	ribosome production factor 2 homolog	VGNC:45710	475029

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ribosome production factor 2 homolog

Macaque	ribosome production factor 2 homolog

Mouse	ribosome production factor 2 homolog

Rat	ribosome production factor 2 homolog

Dog	ribosome production factor 2 homolog

Publication Statistics

PubMed Score 25.49

PubMed score by year

PubTator Score 3.78

PubTator score by year

Related Publications

Text Mined References (14)

GeneRif Annotations (1)

Items per page:

0 of 0

PMID	Year	Title

No Header	No Header
Complete proteome

Nucleus

Polymorphism

Reference proteome

Ribosome biogenesis