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Tbio
RPAP3
RNA polymerase II-associated protein 3

Protein Summary
Description
Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. This gene encodes an RNA polymerase II-associated protein. The encoded protein may function in transcriptional regulation and may also regulate apoptosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000005386
  • ENSP00000005386
  • ENSG00000005175
  • ENST00000380650
  • ENSP00000370024
  • ENST00000432584
  • ENSP00000401823

Symbol
  • Tah1
  • hSpagh
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
histone modification site profile
0.74
protein domain
0.73
disease perturbation
0.68
tissue sample
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.63   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.63   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (91)
PIH1D1
Tbio
Novelty:  0.10737369
p_int:  0.999760255
p_ni:  0.000239745
Score:  0.998
Data Source:  BioPlex,STRINGDB
URI1
Tbio
Family:  Enzyme
Novelty:  0.04265162
p_int:  0.999595203
p_ni:  0.000404797
Score:  0.71
Data Source:  BioPlex,STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.997706211
p_ni:  0.002293789
Score:  0.844
Data Source:  BioPlex,STRINGDB
UXT
Tbio
Novelty:  0.0272609
p_int:  0.995458839
p_ni:  0.004541162
Score:  0.925
Data Source:  BioPlex,STRINGDB
POLR3A
Tbio
Family:  Enzyme
Novelty:  0.01508849
p_int:  0.992543396
p_ni:  0.007456604
Score:  0.501
Data Source:  BioPlex,STRINGDB
WDR92
Tbio
Novelty:  55
p_int:  0.991014709
p_ni:  0.008985291
Score:  0.567
Data Source:  BioPlex,STRINGDB
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.98725701
p_ni:  0.01274299
Score:  0.767
Data Source:  BioPlex,STRINGDB
PDRG1
Tbio
Novelty:  0.09389276
p_int:  0.958505507
p_ni:  0.041493974
p_wrong:  5.19e-7
Score:  0.795
Data Source:  BioPlex,STRINGDB
ASB7
Tdark
Novelty:  0.21883348
p_int:  0.915215865
p_ni:  0.084784135
Score:  0.828
Data Source:  BioPlex,STRINGDB
RUVBL1
Tbio
Novelty:  0.0089115
p_int:  0.850592071
p_ni:  0.149407929
Score:  0.998
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
70.2
waist-hip ratio
1
1
1
69.5
BMI-adjusted waist-hip ratio
6
1
6
67.7
1
1
0
1.1
66.3
body mass index
1
1
1
64.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
70.2
waist-hip ratio
1
69.5
BMI-adjusted waist-hip ratio
6
67.7
0
1.1
66.3
body mass index
1
64.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase II associated protein 3
VGNC:8608
451854
Macaque
RNA polymerase II associated protein 3
703749
Mouse
MGI:1277218
71919
Rat
RGD:1303036
300189
Dog
RNA polymerase II associated protein 3
VGNC:45707
477631
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase II associated protein 3
Macaque
RNA polymerase II associated protein 3
Mouse
Rat
Dog
RNA polymerase II associated protein 3
Publication Statistics
PubMed Score 52.63
PubMed score by year
PubTator Score 8.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title