You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

Protein Summary
Description
Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610020
  • ENSP00000476948
  • ENSG00000122484

Symbol
  • C1orf82
  • Rtr1
  • C1orf82
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
kinase perturbation
0.88
transcription factor perturbation
0.8
cellular component
0.69
disease perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.81   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.81   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (151)
LMO2
Tbio
Novelty:  0.0038279
p_int:  0.999994677
p_ni:  0.000005323
Score:  0.519
Data Source:  BioPlex,STRINGDB
POLR2J
Tbio
Family:  Enzyme
Novelty:  0.02344868
p_int:  0.999993187
p_ni:  0.000006813
Score:  0.987
Data Source:  BioPlex,STRINGDB
POLR2G
Tbio
Family:  Enzyme
Novelty:  0.01235379
p_int:  0.999990731
p_ni:  0.000009269
Score:  0.994
Data Source:  BioPlex,STRINGDB
GPN3
Tbio
Family:  Enzyme
Novelty:  0.13817794
p_int:  0.999983337
p_ni:  0.000016663
Score:  0.947
Data Source:  BioPlex,STRINGDB
PIH1D1
Tbio
Novelty:  0.10737369
p_int:  0.999945259
p_ni:  0.000054741
Score:  0.881
Data Source:  BioPlex,STRINGDB
RPRD1B
Tbio
Novelty:  0.0444394
p_int:  0.99990413
p_ni:  0.00009587
Score:  0.994
Data Source:  BioPlex,Reactome,STRINGDB
GPN1
Tbio
Family:  Enzyme
Novelty:  0.06883613
p_int:  0.999889175
p_ni:  0.000110825
Score:  0.941
Data Source:  BioPlex,STRINGDB
Q6EEV4
Tbio
Family:  Enzyme
Novelty:  0.11413088
p_int:  0.999850099
p_ni:  0.000149901
Score:  0.809
Data Source:  BioPlex,STRINGDB
POLR2D
Tdark
Family:  Enzyme
Novelty:  0.11021614
p_int:  0.999765861
p_ni:  0.000234139
Score:  0.991
Data Source:  BioPlex,STRINGDB
ASB6
Tdark
Novelty:  0.32074223
p_int:  0.999469498
p_ni:  0.000530502
Score:  0.632
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Transcription
Reactome
RNA polymerase II transcribes snRNA genes
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase II Transcription
RNA polymerase II transcribes snRNA genes
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
4
4
98.1
monocyte count
1
2
2
95.7
granulocyte percentage of myeloid white cells
1
2
2
95
lymphocyte percentage of leukocytes
2
2
2
83.1
myeloid white cell count
2
2
2
81.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
4
98.1
monocyte count
2
95.7
granulocyte percentage of myeloid white cells
2
95
lymphocyte percentage of leukocytes
2
83.1
myeloid white cell count
2
81.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
RNA polymerase II associated protein 2
706358
Mouse
MGI:2141142
231571
Rat
RGD:1309034
305120
Horse
RNA polymerase II associated protein 2
VGNC:22513
100059972
Cow
RNA polymerase II associated protein 2
VGNC:34099
529184
Species
Name
OMA
EggNOG
Inparanoid
Macaque
RNA polymerase II associated protein 2
Mouse
Rat
Horse
RNA polymerase II associated protein 2
Cow
RNA polymerase II associated protein 2
Publication Statistics
PubMed Score 33.81
PubMed score by year
PubTator Score 10.63
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title