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Tbio
RPA4
Replication protein A 30 kDa subunit

Protein Summary
Description
As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange. This gene encodes a single-stranded DNA-binding protein that is the 30-kDa subunit of the replication protein A complex. Replication protein A is an essential factor for DNA double-strand break repair and cell cycle checkpoint activation. The encoded protein localizes to DNA repair foci and may be involved in the cellular DNA damage response. This protein may also play a role in inhibiting viral replication.[provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373040
  • ENSP00000362131
  • ENSG00000204086

Symbol
  • HSU24186
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
cell type or tissue
0.56
tissue
0.51
tissue sample
0.51
cellular component
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.8   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.8   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (107)
HMCES
Tbio
Family:  Enzyme
Novelty:  0.01229889
p_int:  0.999426016
p_ni:  0.000573984
Score:  0.261
Data Source:  BioPlex,STRINGDB
XPC
Tbio
Novelty:  0.00775175
p_int:  0.999211292
p_ni:  0.000788708
Score:  0.798
Data Source:  BioPlex,STRINGDB
PARP2
Tclin
Family:  Enzyme
Novelty:  0.00545618
p_int:  0.990337022
p_ni:  0.009662975
p_wrong:  3e-9
Score:  0.462
Data Source:  BioPlex,STRINGDB
RPA1
Tchem
Novelty:  0.00212665
p_int:  0.990243727
p_ni:  0.009756273
Score:  0.985
Data Source:  BioPlex,Reactome,STRINGDB
RPA3
Tbio
Novelty:  0.00887858
p_int:  0.976837784
p_ni:  0.023162216
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
SUPT16H
Tbio
Family:  Enzyme
Novelty:  0.01026868
p_int:  0.939132236
p_ni:  0.060867764
Score:  0.395
Data Source:  BioPlex,STRINGDB
PARP1
Tclin
Family:  Enzyme
Novelty:  0.00033016
p_int:  0.912000067
p_ni:  0.087999933
Score:  0.609
Data Source:  BioPlex,STRINGDB
PRIM1
Tbio
Family:  Enzyme
Novelty:  0.0530384
Score:  0.971
Data Source:  STRINGDB
MCM7
Tbio
Novelty:  0.0017984
Score:  0.971
Data Source:  STRINGDB
MCM5
Tbio
Novelty:  0.00716583
Score:  0.97
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Activation of the pre-replicative complex (R-HSA-68962)

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Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the pre-replicative complex
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
DNA Replication
Reactome
DNA Replication Pre-Initiation
Name
Explore in Pharos
Explore in Source
Activation of the pre-replicative complex
Cell Cycle
Cell Cycle, Mitotic
DNA Replication
DNA Replication Pre-Initiation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
S.cerevisiae
S000005256
855404
Species
Name
OMA
EggNOG
Inparanoid
S.cerevisiae
Publication Statistics
PubMed Score 16.80
PubMed score by year
PubTator Score 9.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title