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Tbio
RP2
Protein XRP2

Protein Summary
Description
Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins. The RP2 locus has been implicated as one cause of X-linked retinitis pigmentosa. The predicted gene product shows homology with human cofactor C, a protein involved in the ultimate step of beta-tubulin folding. Progressive retinal degeneration may therefore be due to the accumulation of incorrectly-folded photoreceptor or neuron-specific tubulin isoforms followed by progressive cell death [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000218340
  • ENSP00000218340
  • ENSG00000102218

Symbol
  • XRP2
  • NME10
  • TBCCD2
  • NM23-H10
  • DELXp11.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.92
biological process
0.9
cellular component
0.66
tissue sample
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.46   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.46   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
OSTF1
Tbio
Novelty:  0.000588
p_int:  0.999999981
p_ni:  1.9e-8
Score:  0.253
Data Source:  BioPlex,STRINGDB
SLC44A2
Tbio
Family:  Transporter
Novelty:  0.01550561
p_int:  0.999999181
p_ni:  1.44e-7
p_wrong:  6.75e-7
Score:  0.313
Data Source:  BioPlex,STRINGDB
MARC2
Tbio
Novelty:  0.05210077
p_int:  0.999953989
p_ni:  0.000045997
p_wrong:  1.3e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
GLMN
Tbio
Novelty:  0.01940401
p_int:  0.999564822
p_ni:  0.000435178
Data Source:  BioPlex
MTOR
Tclin
Family:  Kinase
Novelty:  0.00012333
p_int:  0.999059578
p_ni:  0.000940422
Data Source:  BioPlex
CSNK1D
Tchem
Family:  Kinase
Novelty:  0.00896935
p_int:  0.998981809
p_ni:  0.001018191
Data Source:  BioPlex
CSNK1E
Tclin
Family:  Kinase
Novelty:  0.00891859
p_int:  0.998696624
p_ni:  0.001303376
Data Source:  BioPlex
DMXL2
Tbio
Novelty:  0.06848356
p_int:  0.995632676
p_ni:  0.004367324
Score:  0.184
Data Source:  BioPlex,STRINGDB
XPO7
Tbio
Novelty:  0.05412704
p_int:  0.993678749
p_ni:  0.006321251
Data Source:  BioPlex
TKFC
Tbio
Family:  Enzyme
Novelty:  0.00380602
p_int:  0.99163695
p_ni:  0.001036844
p_wrong:  0.007326207
Score:  0.165
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Cargo trafficking to the periciliary membrane (R-HSA-5620920)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Reactome
Trafficking of myristoylated proteins to the cilium
Name
Explore in Pharos
Explore in Source
Cargo trafficking to the periciliary membrane
Cilium Assembly
Organelle biogenesis and maintenance
Trafficking of myristoylated proteins to the cilium
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RP2, ARL3 GTPase activating protein
VGNC:14717
465596
Macaque
RP2, ARL3 GTPase activating protein
711227
Mouse
MGI:1277953
19889
Rat
RGD:1565124
367714
Dog
RP2, ARL3 GTPase activating protein
VGNC:45700
491853
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RP2, ARL3 GTPase activating protein
Macaque
RP2, ARL3 GTPase activating protein
Mouse
Rat
Dog
RP2, ARL3 GTPase activating protein
Publication Statistics
PubMed Score 7.46
PubMed score by year
PubTator Score 193.25
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title