Tclin ROS1 Proto-oncogene tyrosine-protein kinase ROS

Protein Summary

Description

Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P08922
• Q15368
• Q5TDB5

Gene Name

• ROS1

Ensembl ID

• ENST00000368508
• ENSP00000357494
• ENSG00000047936

Symbol

• MCF3
• ROS
• ROS
• MCF3
• c-ros-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.99
gene perturbation	0.63
biological process	0.55
cell line	0.51

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Sev Family / Proto-oncogene Tyrosine-protein Kinase Ros

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 987.92   (req: < 5)

Gene RIFs: 171   (req: <= 3)

Antibodies: 594   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 987.92   (req: >= 5)

Gene RIFs: 171   (req: > 3)

Antibodies: 594   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 98

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6