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Tchem
RORC
Nuclear receptor ROR-gamma

Protein Summary
Description
Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism (PubMed:19381306, PubMed:19965867, PubMed:22789990, PubMed:26160376, PubMed:20203100). Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively (PubMed:19965867, PubMed:22789990). Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318247
  • ENSP00000327025
  • ENSG00000143365
  • ENST00000356728
  • ENSP00000349164

Symbol
  • NR1F3
  • RORG
  • RZRG
  • TOR
  • RORG
  • RZRG
  • IMD42
  • NR1F3
  • RZR-GAMMA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
molecular function
0.95
protein domain
0.85
transcription factor
0.67
microRNA
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.76   (req: < 5)
Gene RIFs: 92   (req: <= 3)
Antibodies: 759   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.76   (req: >= 5)
Gene RIFs: 92   (req: > 3)
Antibodies: 759   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1544
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0