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Tbio
ROGDI
Protein rogdi homolog

Protein Summary
Description
This gene encodes a protein of unknown function. Loss-of-function mutation in this gene cause Kohlschutter-Tonz syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322048
  • ENSP00000322832
  • ENSG00000067836

Symbol
  • KTZS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
histone modification site profile
0.79
cell line
0.56
transcription factor
0.56
tissue sample
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.52   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.52   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
DMXL1
Tdark
Novelty:  0.0234264
p_int:  1
Score:  0.309
Data Source:  BioPlex,STRINGDB
WDR7
Tdark
Novelty:  0.00602015
p_int:  1
Score:  0.261
Data Source:  BioPlex,STRINGDB
DMXL2
Tbio
Novelty:  0.06848356
p_int:  0.999999994
p_ni:  6e-9
Score:  0.204
Data Source:  BioPlex,STRINGDB
ATP1A2
Tclin
Family:  Transporter
Novelty:  0.00606202
p_int:  0.999960708
p_ni:  7.92e-7
p_wrong:  0.000038501
Score:  0.409
Data Source:  BioPlex,STRINGDB
MYH7
Tclin
Novelty:  0.00268092
p_int:  0.998468173
p_ni:  0.001526414
p_wrong:  0.000005413
Score:  0.196
Data Source:  BioPlex,STRINGDB
TUBA3C
Tchem
Novelty:  0.0187396
p_int:  0.997801912
p_ni:  0.002198088
Data Source:  BioPlex
ATP2A1
Tchem
Family:  Transporter
Novelty:  0.00355092
p_int:  0.997114029
p_ni:  0.002885971
Score:  0.219
Data Source:  BioPlex,STRINGDB
MYH8
Tbio
Novelty:  0.01020559
p_int:  0.996964407
p_ni:  0.000093057
p_wrong:  0.002942536
Score:  0.261
Data Source:  BioPlex,STRINGDB
SMYD4
Tbio
Family:  Epigenetic
Novelty:  0.18455037
Score:  0.726
Data Source:  STRINGDB
ACP4
Tbio
Family:  Enzyme
Novelty:  0.01397537
Score:  0.725
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
LIFEdb
Inferred from Direct Assay (IDA)
HGNC
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
76.3
waist-hip ratio
2
2
2
53.2
diastolic blood pressure
1
1
1
49.7
mean platelet volume
1
1
1
48
high density lipoprotein cholesterol measurement
1
1
1
45.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
76.3
waist-hip ratio
2
53.2
diastolic blood pressure
1
49.7
mean platelet volume
1
48
high density lipoprotein cholesterol measurement
1
45.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
rogdi homolog
VGNC:5911
750319
Macaque
rogdi homolog
706735
Mouse
MGI:1913299
66049
Rat
RGD:1560021
287061
Dog
rogdi homolog
VGNC:45689
479861
Species
Name
OMA
EggNOG
Inparanoid
Chimp
rogdi homolog
Macaque
rogdi homolog
Mouse
Rat
Dog
rogdi homolog
Publication Statistics
PubMed Score 16.52
PubMed score by year
PubTator Score 10.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title