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Tclin
ROCK2
Rho-associated protein kinase 2

Protein Summary
Description
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315872
  • ENSP00000317985
  • ENSG00000134318

Symbol
  • KIAA0619
  • ROCK-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
kinase perturbation
0.91
biological process
0.84
transcription factor binding site profile
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 445.08   (req: < 5)
Gene RIFs: 143   (req: <= 3)
Antibodies: 625   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 445.08   (req: >= 5)
Gene RIFs: 143   (req: > 3)
Antibodies: 625   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 56
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 959
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (169)
POLR1C
Tbio
Family:  Enzyme
Novelty:  0.04485332
p_int:  0.999999973
p_ni:  2.7e-8
Score:  0.208
Data Source:  BioPlex,STRINGDB
ROCK1
Tclin
Family:  Kinase
Novelty:  0.00156045
p_int:  0.999999679
p_ni:  3.3e-8
p_wrong:  2.89e-7
Score:  0.987
Data Source:  BioPlex,STRINGDB
DNAJB11
Tbio
Novelty:  0.02588745
p_int:  0.999998186
p_ni:  0.000001814
Score:  0.254
Data Source:  BioPlex,STRINGDB
FBXO42
Tbio
Novelty:  0.17658866
p_int:  0.999775981
p_ni:  0.000224019
Score:  0.318
Data Source:  BioPlex,STRINGDB
LRPAP1
Tbio
Novelty:  0.00214194
p_int:  0.999636482
p_ni:  0.000363144
p_wrong:  3.73e-7
Score:  0.214
Data Source:  BioPlex,STRINGDB
ADD2
Tbio
Family:  Enzyme
Novelty:  0.01097975
p_int:  0.989967403
p_ni:  0.009995901
p_wrong:  0.000036696
Score:  0.774
Data Source:  BioPlex,STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.995
Data Source:  Reactome,STRINGDB
PPP1R12A
Tbio
Family:  Enzyme
Novelty:  0.0028297
Score:  0.992
Data Source:  Reactome,STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.986
Data Source:  STRINGDB
RHOC
Tbio
Family:  Enzyme
Novelty:  0.00262213
Score:  0.979
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (60)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPHA-mediated growth cone collapse
Reactome
EPHB-mediated forward signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPHB-mediated forward signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (61)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Non-traceable Author Statement (NAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
74
mean corpuscular volume
1
1
1
69.4
electrocardiography
1
1
3
45.2
waist-hip ratio
1
1
1
39.6
BMI-adjusted waist-hip ratio
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
74
mean corpuscular volume
1
69.4
electrocardiography
3
45.2
waist-hip ratio
1
39.6
BMI-adjusted waist-hip ratio
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho associated coiled-coil containing protein kinase 2
VGNC:6655
470307
Macaque
Rho associated coiled-coil containing protein kinase 2
708444
Mouse
MGI:107926
19878
Rat
RGD:3590
25537
Dog
Rho associated coiled-coil containing protein kinase 2
VGNC:49640
482970
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho associated coiled-coil containing protein kinase 2
Macaque
Rho associated coiled-coil containing protein kinase 2
Mouse
Rat
Dog
Rho associated coiled-coil containing protein kinase 2
Publication Statistics
PubMed Score 445.08
PubMed score by year
PubTator Score 224.71
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title