You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RNH1
Ribonuclease inhibitor

Protein Summary
Description
Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis. Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354420
  • ENSP00000346402
  • ENSG00000023191
  • ENST00000356187
  • ENSP00000348515
  • ENST00000397604
  • ENSP00000380729
  • ENST00000397614
  • ENSP00000380738
  • ENST00000397615
  • ENSP00000380739
  • ENST00000438658
  • ENSP00000416589
  • ENST00000533410
  • ENSP00000435594
  • ENST00000534797
  • ENSP00000433999
  • ENST00000612988
  • ENSP00000479004
  • ENSG00000276230
  • ENST00000617351
  • ENSP00000484572
  • ENST00000618184
  • ENSP00000478664
  • ENST00000619599
  • ENSP00000479966
  • ENST00000621211
  • ENSP00000480036
  • ENST00000632527
  • ENSP00000487940
  • ENST00000632954
  • ENSP00000487753
  • ENST00000633287
  • ENSP00000488734

Symbol
  • PRI
  • RNH
  • RAI
  • RNH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
transcription factor
0.88
transcription factor binding site profile
0.83
tissue sample
0.72
interacting protein
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 287.17   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 411   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 287.17   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 411   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
HOXB6
Tbio
Family:  TF
Novelty:  0.0176813
p_int:  0.999999996
p_ni:  3e-9
p_wrong:  1e-9
Data Source:  BioPlex
ZNF282
Tdark
Family:  TF
Novelty:  0.32333465
p_int:  0.999999996
p_ni:  3e-9
Data Source:  BioPlex
HOXC4
Tbio
Family:  TF
Novelty:  0.02206351
p_int:  0.999999987
p_wrong:  1.2e-8
Data Source:  BioPlex
HOXC6
Tbio
Family:  TF
Novelty:  0.00991192
p_int:  0.999999623
p_ni:  6e-9
p_wrong:  3.71e-7
Data Source:  BioPlex
UBA52
Tbio
Novelty:  0.01637744
p_int:  0.999998862
p_ni:  0.000001138
Score:  0.26
Data Source:  BioPlex,STRINGDB
RNASE4
Tbio
Family:  Enzyme
Novelty:  17
p_int:  0.99999719
p_ni:  1.68e-7
p_wrong:  0.000002642
Data Source:  BioPlex
HOXA5
Tbio
Family:  TF
Novelty:  0.0058504
p_int:  0.999992012
p_ni:  0.000007986
p_wrong:  2e-9
Data Source:  BioPlex
CDC20
Tbio
Novelty:  0.00197887
p_int:  0.999978093
p_ni:  0.000021907
Score:  0.153
Data Source:  BioPlex,STRINGDB
MRM2
Tbio
Family:  Enzyme
Novelty:  0.06394065
p_int:  0.999977068
p_ni:  0.00002248
p_wrong:  4.52e-7
Data Source:  BioPlex
HOXB9
Tbio
Family:  TF
Novelty:  0.01591519
p_int:  0.999906984
p_ni:  0.000093015
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
2
2
64.4
3
2
0
1.2
54.2
apolipoprotein A 1 measurement
1
1
1
28.1
lymphocyte count
1
1
1
13.9
reticulocyte count
1
1
1
11.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
64.4
0
1.2
54.2
apolipoprotein A 1 measurement
1
28.1
lymphocyte count
1
13.9
reticulocyte count
1
11.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribonuclease/angiogenin inhibitor 1
450154
Macaque
ribonuclease/angiogenin inhibitor 1
720791
Mouse
MGI:1195456
107702
Rat
RGD:621398
100360501
Dog
ribonuclease/angiogenin inhibitor 1
VGNC:45680
483402
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribonuclease/angiogenin inhibitor 1
Macaque
ribonuclease/angiogenin inhibitor 1
Mouse
Rat
Dog
ribonuclease/angiogenin inhibitor 1
Publication Statistics
PubMed Score 287.17
PubMed score by year
PubTator Score 135.89
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title