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Tbio
RNH1
Ribonuclease inhibitor

Protein Summary
Description
Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis. Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354420
  • ENSP00000346402
  • ENSG00000023191
  • ENST00000356187
  • ENSP00000348515
  • ENST00000397604
  • ENSP00000380729
  • ENST00000397614
  • ENSP00000380738
  • ENST00000397615
  • ENSP00000380739
  • ENST00000438658
  • ENSP00000416589
  • ENST00000533410
  • ENSP00000435594
  • ENST00000534797
  • ENSP00000433999
  • ENST00000612988
  • ENSP00000479004
  • ENSG00000276230
  • ENST00000617351
  • ENSP00000484572
  • ENST00000618184
  • ENSP00000478664
  • ENST00000619599
  • ENSP00000479966
  • ENST00000621211
  • ENSP00000480036
  • ENST00000632527
  • ENSP00000487940
  • ENST00000632954
  • ENSP00000487753
  • ENST00000633287
  • ENSP00000488734

Symbol
  • PRI
  • RNH
  • RAI
  • RNH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
transcription factor
0.88
transcription factor binding site profile
0.83
tissue sample
0.72
interacting protein
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 558.93   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 411   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 558.93   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 411   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0