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Tdark
RNFT2
RING finger and transmembrane domain-containing protein 2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257575
  • ENSP00000257575
  • ENSG00000135119
  • ENST00000392549
  • ENSP00000376332
  • ENST00000407967
  • ENSP00000385669

Symbol
  • TMEM118
  • TMEM118
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.73
transcription factor binding site profile
0.71
histone modification site profile
0.67
transcription factor
0.58
kinase perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.62   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 33   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.62   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 33   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
UBE2G2
Tbio
Novelty:  0.04298958
Score:  0.771
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.72
Data Source:  STRINGDB
RNF144A
Tbio
Family:  Enzyme
Novelty:  0.13172374
Score:  0.705
Data Source:  STRINGDB
RNF223
Tdark
Novelty:  8.91891892
Score:  0.677
Data Source:  STRINGDB
RNF183
Tbio
Novelty:  0.34873861
Score:  0.654
Data Source:  STRINGDB
C6orf201
Tdark
Novelty:  51
Score:  0.641
Data Source:  STRINGDB
RNF144B
Tbio
Family:  Enzyme
Novelty:  0.02487971
Score:  0.611
Data Source:  STRINGDB
TMEM129
Tbio
Family:  Enzyme
Novelty:  0.53527143
Score:  0.609
Data Source:  STRINGDB
LONRF2
Tdark
Family:  Enzyme
Novelty:  1.01811251
Score:  0.608
Data Source:  STRINGDB
LRRC40
Tdark
Novelty:  2.43377466
Score:  0.605
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hippocampal volume
4
2
0
59.1
82.7
brain volume measurement
1
2
0
52
65.4
apolipoprotein A 1 measurement
1
1
1
63.4
hippocampal CA1 volume
1
1
0
24.1
36.5
granule cell layer dentate gyrus volume
1
1
0
11
34.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hippocampal volume
0
59.1
82.7
brain volume measurement
0
52
65.4
apolipoprotein A 1 measurement
1
63.4
hippocampal CA1 volume
0
24.1
36.5
granule cell layer dentate gyrus volume
0
11
34.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein, transmembrane 2
VGNC:5574
452284
Macaque
ring finger protein, transmembrane 2
693339
Mouse
MGI:2442859
269695
Rat
RGD:1560195
304521
Dog
ring finger protein, transmembrane 2
VGNC:45678
611303
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein, transmembrane 2
Macaque
ring finger protein, transmembrane 2
Mouse
Rat
Dog
ring finger protein, transmembrane 2
Publication Statistics
PubMed Score 1.62
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title