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Tdark
RNFT1
E3 ubiquitin-protein ligase RNFT1

Protein Summary
Description
E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305783
  • ENSP00000304670
  • ENSG00000189050
  • ENST00000482446
  • ENSP00000436144

Symbol
  • PTD016
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.78
transcription factor perturbation
0.68
cell line
0.55
tissue sample
0.54
cellular component
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.71   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.71   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (48)
IL17RB
Tbio
Novelty:  0.01540031
p_int:  0.999703018
p_ni:  0.000009179
p_wrong:  0.000287803
Score:  0.219
Data Source:  BioPlex,STRINGDB
TMEM63C
Tdark
Family:  IC
Novelty:  0.02849254
p_int:  0.999594271
p_ni:  0.000011152
p_wrong:  0.000394578
Data Source:  BioPlex
REEP5
Tbio
Novelty:  0.00160455
p_int:  0.997652753
p_ni:  2.78e-7
p_wrong:  0.002346969
Score:  0.188
Data Source:  BioPlex,STRINGDB
UBE2G2
Tbio
Novelty:  0.04298958
Score:  0.774
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.72
Data Source:  STRINGDB
RNF223
Tdark
Novelty:  8.91891892
Score:  0.715
Data Source:  STRINGDB
RNF19B
Tbio
Family:  Enzyme
Novelty:  0.20054824
Score:  0.708
Data Source:  STRINGDB
RNF170
Tbio
Family:  Enzyme
Novelty:  0.1117879
Score:  0.677
Data Source:  STRINGDB
RNF144A
Tbio
Family:  Enzyme
Novelty:  0.13172374
Score:  0.672
Data Source:  STRINGDB
CGRRF1
Tdark
Novelty:  0.49690187
Score:  0.659
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
3
4
94.7
blood protein measurement
1
2
2
88.2
serum non-albumin protein measurement
1
2
2
86.8
C-reactive protein measurement
2
2
2
79.3
bilirubin measurement
2
1
2
72.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
94.7
blood protein measurement
2
88.2
serum non-albumin protein measurement
2
86.8
C-reactive protein measurement
2
79.3
bilirubin measurement
2
72.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein, transmembrane 1
VGNC:9572
454808
Macaque
ring finger protein, transmembrane 1
712052
Mouse
MGI:1924142
76892
Rat
RGD:1562411
360595
Dog
ring finger protein, transmembrane 1
VGNC:45677
480581
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein, transmembrane 1
Macaque
ring finger protein, transmembrane 1
Mouse
Rat
Dog
ring finger protein, transmembrane 1
Publication Statistics
PubMed Score 0.71
PubMed score by year
PubTator Score 0.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title