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Tbio
RNF41
E3 ubiquitin-protein ligase NRDP1

Protein Summary
Description
Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345093
  • ENSP00000342755
  • ENSG00000181852
  • ENST00000394013
  • ENSP00000377581
  • ENST00000552656
  • ENSP00000447303
  • ENST00000615206
  • ENSP00000484671

Symbol
  • FLRF
  • NRDP1
  • FLRF
  • NRDP1
  • SBBI03
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
protein domain
0.97
microRNA
0.92
transcription factor perturbation
0.91
molecular function
0.9


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.67   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.67   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (349)
SHTN1
Tbio
Novelty:  0.06452923
p_int:  0.999999856
p_ni:  3.7e-8
p_wrong:  1.06e-7
Data Source:  BioPlex
VPS52
Tbio
Novelty:  0.01439614
p_int:  0.999989338
p_ni:  0.000010662
Score:  0.621
Data Source:  BioPlex,STRINGDB
SRR
Tbio
Family:  Enzyme
Novelty:  0.00425993
p_int:  0.999988404
p_ni:  0.000011596
Score:  0.213
Data Source:  BioPlex,STRINGDB
LCP1
Tbio
Novelty:  0.0035357
p_int:  0.999985813
p_ni:  0.000014187
Score:  0.187
Data Source:  BioPlex,STRINGDB
ENOPH1
Tbio
Family:  Enzyme
Novelty:  0.07679925
p_int:  0.999980051
p_ni:  0.000019948
p_wrong:  1e-9
Score:  0.366
Data Source:  BioPlex,STRINGDB
TTC1
Tbio
Novelty:  0.01389711
p_int:  0.999974282
p_ni:  0.000025717
p_wrong:  1e-9
Score:  0.246
Data Source:  BioPlex,STRINGDB
SOGA1
Tbio
Novelty:  0.08349978
p_int:  0.999970709
p_ni:  0.000029291
Data Source:  BioPlex
ASB6
Tdark
Novelty:  0.32074223
p_int:  0.999945918
p_ni:  0.000046815
p_wrong:  0.000007267
Score:  0.943
Data Source:  BioPlex,STRINGDB
TACC1
Tbio
Novelty:  0.03556945
p_int:  0.999909518
p_ni:  0.000090075
p_wrong:  4.08e-7
Score:  0.177
Data Source:  BioPlex,STRINGDB
SNCAIP
Tbio
Novelty:  0.01355161
p_int:  0.999779643
p_ni:  0.000219543
p_wrong:  8.14e-7
Data Source:  BioPlex
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
1 – 5 of 6
FGFR2
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
IGF1R
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
EGFR
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
FGFR4
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
FGFR3
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
Pathways (46)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Downregulation of ERBB2 signaling
Reactome
Downregulation of ERBB2:ERBB3 signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Downregulation of ERBB2 signaling
Downregulation of ERBB2:ERBB3 signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
5
8
9
99.5
1
1
0
1.5
53.7
risk-taking behaviour
1
1
1
33.1
self reported educational attainment
1
1
1
33.1
BMI-adjusted waist circumference
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
9
99.5
0
1.5
53.7
risk-taking behaviour
1
33.1
self reported educational attainment
1
33.1
BMI-adjusted waist circumference
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1914838
67588
Rat
RGD:1309557
362814
Dog
ring finger protein 41
VGNC:45670
607044
Horse
ring finger protein 41
VGNC:22481
100052095
Cow
ring finger protein 41
VGNC:34067
614134
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
ring finger protein 41
Horse
ring finger protein 41
Cow
ring finger protein 41
Publication Statistics
PubMed Score 64.67
PubMed score by year
PubTator Score 36.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title