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Tbio
RNF4
E3 ubiquitin-protein ligase RNF4

Protein Summary
Description
E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation. The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314289
  • ENSP00000315212
  • ENSG00000063978
  • ENST00000506706
  • ENSP00000424076
  • ENST00000511600
  • ENSP00000426503
  • ENST00000511859
  • ENSP00000426615
  • ENST00000541204
  • ENSP00000446369

Symbol
  • SNURF
  • SLX5
  • SNURF
  • RES4-26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
kinase perturbation
0.91
transcription factor binding site profile
0.86
hub protein
0.85
microRNA
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.36   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.36   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0