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Tbio
RNF26
E3 ubiquitin-protein ligase RNF26

Protein Summary
Description
E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud (PubMed:27368102). Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 (PubMed:27368102). Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102). Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING (PubMed:25254379). Also required to limit type I interferon response by promoting autophagic degradation of IRF3 (PubMed:25254379). The protein encoded by this intronless gene contains a C3HC5 type of RING finger, a motif known to be involved in protein-DNA and protein-protein interac ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311413
  • ENSP00000312439
  • ENSG00000173456
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
transcription factor perturbation
0.68
tissue sample
0.67
histone modification site profile
0.66
tissue
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.59   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.59   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
ZNF143
Tbio
Family:  TF
Novelty:  0.00622649
p_int:  0.999999991
p_ni:  8e-9
p_wrong:  1e-9
Score:  0.407
Data Source:  BioPlex,STRINGDB
TMEM159
Tdark
Novelty:  0.22237677
p_int:  0.999280382
p_ni:  1.7e-8
p_wrong:  0.000719601
Data Source:  BioPlex
CUEDC2
Tbio
Novelty:  0.07403123
p_int:  0.998548387
p_ni:  0.000482909
p_wrong:  0.000968703
Score:  0.197
Data Source:  BioPlex,STRINGDB
NME2P1
Tdark
Family:  Kinase
p_int:  0.989005588
p_ni:  0.010994412
Data Source:  BioPlex
ZMPSTE24
Tbio
Family:  Enzyme
Novelty:  0.0027993
p_int:  0.938215275
p_ni:  0.061768462
p_wrong:  0.000016263
Score:  0.198
Data Source:  BioPlex,STRINGDB
PSME2
Tbio
Novelty:  0.02624268
p_int:  0.886368217
p_ni:  0.11362851
p_wrong:  0.000003273
Score:  0.175
Data Source:  BioPlex,STRINGDB
PSME1
Tbio
Novelty:  0.01258149
p_int:  0.859391315
p_ni:  0.140608685
Score:  0.191
Data Source:  BioPlex,STRINGDB
ETF1
Tbio
Family:  Enzyme
Novelty:  0.00711627
p_int:  0.839523248
p_ni:  0.160476752
Score:  0.211
Data Source:  BioPlex,STRINGDB
NAA50
Tchem
Family:  Enzyme
Novelty:  0.01843508
p_int:  0.821674195
p_ni:  0.178323429
p_wrong:  0.000002377
Score:  0.199
Data Source:  BioPlex,STRINGDB
TMEM173
Tchem
Novelty:  0.0070581
Score:  0.785
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
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1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
2
2
90.5
urate measurement
4
3
4
86.3
platelet count
1
1
1
76.8
reticulocyte count
6
1
6
76.4
reticulocyte measurement
2
1
2
74.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
90.5
urate measurement
4
86.3
platelet count
1
76.8
reticulocyte count
6
76.4
reticulocyte measurement
2
74.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 26
VGNC:1014
451607
Mouse
MGI:2388131
213211
Mouse
MGI:3644000
668155
Rat
RGD:1305953
300659
Dog
ring finger protein 26
VGNC:45666
489367
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 26
Mouse
Mouse
Rat
Dog
ring finger protein 26
Publication Statistics
PubMed Score 3.59
PubMed score by year
PubTator Score 1.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title