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Tbio
RNF25
E3 ubiquitin-protein ligase RNF25

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). Stimulates transcription mediated by NF-kappa-B. The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295704
  • ENSP00000295704
  • ENSG00000163481

Symbol
  • AO7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
cell type or tissue
0.83
gene perturbation
0.69
tissue sample
0.64
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.02   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.02   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (293)
UBE2D2
Tbio
Novelty:  0.00603877
p_int:  1
Score:  0.994
Data Source:  BioPlex,STRINGDB
UBE2E3
Tbio
Novelty:  0.03477232
p_int:  1
Score:  0.958
Data Source:  BioPlex,STRINGDB
UBE2E2
Tbio
Novelty:  0.02752227
p_int:  1
Score:  0.934
Data Source:  BioPlex,STRINGDB
UBE2D4
Tbio
Novelty:  0.40836104
p_int:  0.999998374
p_ni:  3.52e-7
p_wrong:  0.000001275
Score:  0.947
Data Source:  BioPlex,STRINGDB
UBE2D1
Tbio
Novelty:  0.00865867
p_int:  0.999973948
p_ni:  0.000026049
p_wrong:  3e-9
Score:  0.962
Data Source:  BioPlex,STRINGDB
UBE2E1
Tbio
Novelty:  0.04048768
p_int:  0.999868673
p_ni:  0.000122447
p_wrong:  0.000008879
Score:  0.95
Data Source:  BioPlex,STRINGDB
RBFOX1
Tbio
Novelty:  0.00571285
p_int:  0.999778657
p_ni:  0.000221338
p_wrong:  4e-9
Score:  0.192
Data Source:  BioPlex,STRINGDB
MINDY3
Tbio
Novelty:  0.02865765
p_int:  0.998605654
p_ni:  0.001394345
p_wrong:  1e-9
Score:  0.211
Data Source:  BioPlex,STRINGDB
UBE2D3
Tchem
Novelty:  0.01908446
p_int:  0.998533934
p_ni:  0.001466066
Score:  0.954
Data Source:  BioPlex,STRINGDB
UCN3
Tbio
Novelty:  0.00996251
p_int:  0.997288849
p_ni:  0.002710782
p_wrong:  3.69e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
2
91.4
hemoglobin measurement
2
2
2
88.4
body mass index
2
1
2
58.4
body height
1
2
2
49.1
waist-hip ratio
1
1
1
45.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
91.4
hemoglobin measurement
2
88.4
body mass index
2
58.4
body height
2
49.1
waist-hip ratio
1
45.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 25
VGNC:2805
459947
Macaque
ring finger protein 25
702423
Mouse
MGI:1890215
57751
Rat
RGD:1311557
301515
Dog
ring finger protein 25
VGNC:45665
478912
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 25
Macaque
ring finger protein 25
Mouse
Rat
Dog
ring finger protein 25
Publication Statistics
PubMed Score 9.02
PubMed score by year
PubTator Score 39.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title