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Tbio
RNF24
RING finger protein 24

Protein Summary
Description
May play a role in TRPCs intracellular trafficking. This gene encodes an integral membrane protein that contains a RING-type zinc finger. The encoded protein may interact with multiple transient receptor potential cation channel subfamily C (TRPC) proteins and regulate the trafficking and insertion of these proteins into the plasma membrane. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336095
  • ENSP00000336753
  • ENSG00000101236
  • ENST00000358395
  • ENSP00000351166
  • ENST00000432261
  • ENSP00000388550
  • ENST00000545616
  • ENSP00000444711

Symbol
  • G1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.79
transcription factor binding site profile
0.78
transcription factor
0.71
kinase perturbation
0.66
tissue sample
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.67   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.67   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (18)
TRPC6
Tchem
Family:  IC
Novelty:  0.00118598
Score:  0.952
Data Source:  STRINGDB
TRPC4
Tchem
Family:  IC
Novelty:  0.00339889
Score:  0.718
Data Source:  STRINGDB
TRPM2
Tchem
Family:  IC
Novelty:  0.0076305
Score:  0.717
Data Source:  STRINGDB
TRPC5
Tchem
Family:  IC
Novelty:  0.00406517
Score:  0.713
Data Source:  STRINGDB
TRPC1
Tbio
Family:  IC
Novelty:  0.00233677
Score:  0.647
Data Source:  STRINGDB
TRPC3
Tchem
Family:  IC
Novelty:  0.00268752
Score:  0.633
Data Source:  STRINGDB
ATP8B4
Tbio
Family:  Transporter
Novelty:  0.19278107
Score:  0.565
Data Source:  STRINGDB
SPEF1
Tdark
Novelty:  0.14564815
Score:  0.478
Data Source:  STRINGDB
NT5DC3
Tdark
Family:  Enzyme
Novelty:  0.05571813
Score:  0.463
Data Source:  STRINGDB
RNF141
Tbio
Novelty:  0.41569575
Score:  0.462
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
1
0
5.6
21.5
body height
1
1
1
17.3
electrocardiography
1
1
2
1.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
0
5.6
21.5
body height
1
17.3
electrocardiography
2
1.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ring finger protein 24
717693
Mouse
MGI:1261771
51902
Dog
ring finger protein 24
VGNC:45664
607703
Horse
ring finger protein 24
VGNC:22474
100629353
Cow
ring finger protein 24
VGNC:34059
767991
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ring finger protein 24
Mouse
Dog
ring finger protein 24
Horse
ring finger protein 24
Cow
ring finger protein 24
Publication Statistics
PubMed Score 10.67
PubMed score by year
PubTator Score 5.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title