Tbio RNF220 E3 ubiquitin-protein ligase RNF220

Protein Summary

Description

E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (PubMed:25266658).

Uniprot Accession IDs

• Q5VTB9
• B3KPJ3
• B4DLZ9
• E9PCS1
• Q4KMX2
• Q9NVP6

Gene Name

• RNF220

Ensembl ID

• ENST00000355387
• ENSP00000347548
• ENSG00000187147
• ENST00000361799
• ENSP00000354872
• ENST00000372247
• ENSP00000361321

Symbol

• C1orf164
• C1orf164

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.79
transcription factor perturbation	0.74
transcription factor	0.68
transcription factor binding site profile	0.65
PubMedID	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.84   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 49   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.84   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0