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Tbio
RNF19B
E3 ubiquitin-protein ligase RNF19B

Protein Summary
Description
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1 (PubMed:16709802, PubMed:27485036). Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells (PubMed:10438909). Protects against staurosporin-induced cell death (PubMed:27485036). This gene encodes a multi-pass membrane protein containing two RING-type and one IBR-type zinc finger motifs. The encoded protin is an E3 ubiquitin-protein ligase that plays a role in the cytotoxic effects of natural killer (NK) cells. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes X and Y in a possible pseudoautosomal region. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000235150
  • ENSP00000235150
  • ENSG00000116514
  • ENST00000356990
  • ENSP00000349482
  • ENST00000373456
  • ENSP00000362555

Symbol
  • IBRDC3
  • NKLAM
  • NKLAM
  • IBRDC3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor perturbation
0.91
kinase perturbation
0.81
disease perturbation
0.79
transcription factor binding site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.78   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.78   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (335)
KIAA0753
Tdark
Novelty:  0.00878365
p_int:  0.99999832
p_ni:  0.000001611
p_wrong:  6.9e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
VPS13C
Tbio
Novelty:  0.05207291
p_int:  0.999914358
p_ni:  0.000085642
Score:  0.214
Data Source:  BioPlex,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.999897162
p_ni:  0.000102838
Score:  0.92
Data Source:  BioPlex,STRINGDB
USP4
Tchem
Family:  Enzyme
Novelty:  0.01101075
p_int:  0.999633881
p_ni:  0.000365812
p_wrong:  3.06e-7
Data Source:  BioPlex
DDX49
Tbio
Family:  Enzyme
Novelty:  0.14100169
p_int:  0.999584201
p_ni:  0.000365802
p_wrong:  0.000049998
Score:  0.199
Data Source:  BioPlex,STRINGDB
USP15
Tbio
Family:  Enzyme
Novelty:  0.0208842
p_int:  0.999153766
p_ni:  0.000846234
Score:  0.155
Data Source:  BioPlex,STRINGDB
USP46
Tbio
Family:  Enzyme
Novelty:  0.04594593
p_int:  0.998866017
p_ni:  0.000982289
p_wrong:  0.000151694
Data Source:  BioPlex
FAM91A1
Tbio
Novelty:  0.76982657
p_int:  0.998846634
p_ni:  0.001153339
p_wrong:  2.7e-8
Data Source:  BioPlex
TOLLIP
Tbio
Novelty:  0.01032371
p_int:  0.998237385
p_ni:  0.001762576
p_wrong:  3.9e-8
Data Source:  BioPlex
MPP5
Tbio
Novelty:  0.01707773
p_int:  0.997826122
p_ni:  0.002173877
p_wrong:  2e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
daytime rest measurement
1
1
1
15.7
mosaic loss of chromosome Y measurement
1
1
1
3.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
daytime rest measurement
1
15.7
mosaic loss of chromosome Y measurement
1
3.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 19B
VGNC:1643
469169
Mouse
MGI:1922484
75234
Dog
ring finger protein 19B
VGNC:45651
478146
Horse
ring finger protein 19B
VGNC:22462
100070073
Cow
ring finger protein 19B
VGNC:34045
509774
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 19B
Mouse
Dog
ring finger protein 19B
Horse
ring finger protein 19B
Cow
ring finger protein 19B
Publication Statistics
PubMed Score 9.78
PubMed score by year
PubTator Score 4.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title