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Tbio
RNF187
E3 ubiquitin-protein ligase RNF187

Protein Summary
Description
E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000639044
  • ENSP00000492846
  • ENSG00000168159
  • ENST00000643343
  • ENSP00000493929
  • ENSG00000285426

Symbol
  • RACO1
  • RACO-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
transcription factor perturbation
0.8
virus perturbation
0.76
histone modification site profile
0.68
microRNA
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.35   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.35   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
TRIM44
Tbio
Novelty:  0.00483553
p_int:  0.999999928
p_ni:  5.8e-8
p_wrong:  1.5e-8
Data Source:  BioPlex
CUL2
Tbio
Novelty:  0.00512916
p_int:  0.999999341
p_ni:  6.59e-7
Data Source:  BioPlex
WDR83
Tbio
Novelty:  0.11602568
p_int:  0.999989491
p_ni:  0.000004014
p_wrong:  0.000006495
Score:  0.19
Data Source:  BioPlex,STRINGDB
CUL5
Tbio
Novelty:  0.00792494
p_int:  0.999958516
p_ni:  0.000041483
p_wrong:  1e-9
Score:  0.174
Data Source:  BioPlex,STRINGDB
ZBTB42
Tbio
Family:  TF
Novelty:  0.54038505
p_int:  0.999946935
p_ni:  0.000053061
p_wrong:  5e-9
Score:  0.219
Data Source:  BioPlex,STRINGDB
LHX6
Tbio
Family:  TF
Novelty:  0.01603143
p_int:  0.999457286
p_ni:  0.00054187
p_wrong:  8.43e-7
Score:  0.196
Data Source:  BioPlex,STRINGDB
ZNF669
Tdark
Family:  TF
Novelty:  2.09725685
p_int:  0.990209001
p_ni:  0.007031511
p_wrong:  0.002759488
Score:  0.213
Data Source:  BioPlex,STRINGDB
ZNF562
Tdark
Family:  TF
Novelty:  12.38372093
p_int:  0.98542643
p_ni:  0.001565021
p_wrong:  0.013008549
Score:  0.263
Data Source:  BioPlex,STRINGDB
ZNF653
Tbio
Family:  TF
Novelty:  1.467544
p_int:  0.970385801
p_ni:  0.027985
p_wrong:  0.001629199
Data Source:  BioPlex
JUN
Tchem
Family:  TF
Novelty:  0.00006856
Score:  0.977
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
5.5
33.1
1
1
0
5.5
33.1
soluble triggering receptor expressed on myeloid cells 2 measurement
1
1
0
15744.7
11.3
soluble triggering receptor expressed on myeloid cells 2 measurement
1
1
0
15744.7
11.3
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
5.5
33.1
0
5.5
33.1
soluble triggering receptor expressed on myeloid cells 2 measurement
0
15744.7
11.3
soluble triggering receptor expressed on myeloid cells 2 measurement
0
15744.7
11.3
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 10.35
PubMed score by year
PubTator Score 3.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title