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Tbio
RNF186
E3 ubiquitin-protein ligase RNF186

Protein Summary
Description
E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress (PubMed:23896122). In that process, stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis (PubMed:23896122).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375121
  • ENSP00000364263
  • ENSG00000178828
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.51
transcription factor
0.49
tissue sample
0.47
cell line
0.43
chemical
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.27   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.27   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (22)
RNF175
Tdark
Novelty:  2.00792695
Score:  0.778
Data Source:  STRINGDB
RNF150
Tdark
Novelty:  0.49393737
Score:  0.72
Data Source:  STRINGDB
RNF182
Tdark
Family:  Enzyme
Novelty:  0.44540458
Score:  0.686
Data Source:  STRINGDB
ZNRF4
Tbio
Novelty:  0.16505328
Score:  0.659
Data Source:  STRINGDB
RNF183
Tbio
Novelty:  0.34873861
Score:  0.659
Data Source:  STRINGDB
BNIP1
Tbio
Novelty:  0.04601895
Score:  0.63
Data Source:  STRINGDB
PLA2G2E
Tchem
Family:  Enzyme
Novelty:  0.13947562
Score:  0.578
Data Source:  STRINGDB
SLC25A45
Tdark
Family:  Transporter
Novelty:  0.61869123
Score:  0.568
Data Source:  STRINGDB
OTUD3
Tbio
Novelty:  0.11839931
Score:  0.559
Data Source:  STRINGDB
CARD9
Tbio
Family:  Enzyme
Novelty:  0.00547101
Score:  0.555
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
6
2
1.3
98.4
creatinine measurement
1
1
1
73.9
glomerular filtration rate
1
1
1
72.3
1
1
0
1.1
32.6
1
1
1
20.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.3
98.4
creatinine measurement
1
73.9
glomerular filtration rate
1
72.3
0
1.1
32.6
1
20.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 186
VGNC:1496
743465
Mouse
MGI:1914075
66825
Rat
RGD:1596075
690433
Dog
ring finger protein 186
VGNC:45649
487400
Horse
ring finger protein 186
VGNC:22460
100071883
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 186
Mouse
Rat
Dog
ring finger protein 186
Horse
ring finger protein 186
Publication Statistics
PubMed Score 9.27
PubMed score by year
PubTator Score 3.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title