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Tbio
RNF183
E3 ubiquitin-protein ligase RNF183

Protein Summary
Description
Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:29507230). Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 (PubMed:29507230). May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297894
  • ENSP00000417943
  • ENSG00000165188
  • ENST00000416588
  • ENSP00000420740
  • ENST00000441031
  • ENSP00000417176
  • ENST00000478815
  • ENSP00000419454
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
tissue sample
0.75
gene perturbation
0.65
protein domain
0.41
tissue
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.93   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.93   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
RNF175
Tdark
Novelty:  2.00792695
Score:  0.671
Data Source:  STRINGDB
RNF186
Tbio
Novelty:  0.15621021
Score:  0.659
Data Source:  STRINGDB
RNFT2
Tdark
Novelty:  0.72733404
Score:  0.654
Data Source:  STRINGDB
RNFT1
Tdark
Novelty:  1.15288082
Score:  0.64
Data Source:  STRINGDB
RNF150
Tdark
Novelty:  0.49393737
Score:  0.63
Data Source:  STRINGDB
FATE1
Tbio
Novelty:  0.04176038
Score:  0.626
Data Source:  STRINGDB
ZNRF4
Tbio
Novelty:  0.16505328
Score:  0.614
Data Source:  STRINGDB
RNF144A
Tbio
Family:  Enzyme
Novelty:  0.13172374
Score:  0.614
Data Source:  STRINGDB
RNF144B
Tbio
Family:  Enzyme
Novelty:  0.02487971
Score:  0.602
Data Source:  STRINGDB
TMEM129
Tbio
Family:  Enzyme
Novelty:  0.53527143
Score:  0.594
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood lead measurement
1
2
2
72.4
neutrophil count
1
1
1
69.4
reticulocyte measurement
2
1
2
62.1
myeloid white cell count
1
1
1
61.4
reticulocyte count
2
1
2
60.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood lead measurement
2
72.4
neutrophil count
1
69.4
reticulocyte measurement
2
62.1
myeloid white cell count
1
61.4
reticulocyte count
2
60.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 183
VGNC:4850
464672
Macaque
ring finger protein 183
705679
Mouse
MGI:1923322
76072
Rat
RGD:1564412
500474
Horse
ring finger protein 183
VGNC:22458
100050237
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 183
Macaque
ring finger protein 183
Mouse
Rat
Horse
ring finger protein 183
Publication Statistics
PubMed Score 6.93
PubMed score by year
PubTator Score 1.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title