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Tbio
RNF152
E3 ubiquitin-protein ligase RNF152

Protein Summary
Description
E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (PubMed:21203937).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312828
  • ENSP00000316628
  • ENSG00000176641
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.6
histone modification site profile
0.56
virus perturbation
0.55
cell line
0.54
disease
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.86   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 2   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.86   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 2   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
RRAGA
Tbio
Novelty:  0.02022668
Score:  0.989
Data Source:  Reactome,STRINGDB
UBE2N
Tchem
Novelty:  0.00620946
Score:  0.933
Data Source:  Reactome,STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.909
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.909
Data Source:  STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.909
Data Source:  STRINGDB
RRAGB
Tbio
Novelty:  0.02279777
Score:  0.907
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.9
Data Source:  STRINGDB
AVL9
Tbio
Novelty:  0.14044287
Score:  0.724
Data Source:  STRINGDB
KBTBD2
Tdark
Novelty:  0.50755656
Score:  0.676
Data Source:  STRINGDB
TNRC18
Tdark
Novelty:  0.32654022
Score:  0.665
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
E3 ubiquitin ligases ubiquitinate target proteins (R-HSA-8866654)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
E3 ubiquitin ligases ubiquitinate target proteins
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Protein ubiquitination
Name
Explore in Pharos
Explore in Source
E3 ubiquitin ligases ubiquitinate target proteins
Metabolism of proteins
Post-translational protein modification
Protein ubiquitination
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ring finger protein 152
699091
Mouse
MGI:2443787
320311
Rat
RGD:1305251
293561
Dog
ring finger protein 152
VGNC:45641
609935
Horse
ring finger protein 152
VGNC:22447
100050623
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ring finger protein 152
Mouse
Rat
Dog
ring finger protein 152
Horse
ring finger protein 152
Publication Statistics
PubMed Score 9.86
PubMed score by year
PubTator Score 2.25
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title