Tdark RNF151 RING finger protein 151

Protein Summary

Description

May be involved in acrosome formation of spermatids.

Uniprot Accession IDs

• Q2KHN1
• Q8NHS5

Gene Name

• RNF151

Ensembl ID

• ENST00000569714
• ENSP00000456566
• ENSG00000179580

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
gene perturbation	0.76
cell type or tissue	0.65
cell line	0.59
PubMedID	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.79   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 26   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.79   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (77)

Explore Interacting Targets

1 – 10 of 77

• See Interactions on String-DB

HIST1H1A

Tbio

Novelty:  0.00123818

p_int:  0.999999457

p_ni:  5.43e-7

Data Source:  BioPlex

TNRC18

Tdark

Novelty:  0.32654022

p_int:  0.999869507

p_ni:  0.000130445

p_wrong:  4.8e-8

Data Source:  BioPlex

PNN

Tbio

Novelty:  0.01395394

p_int:  0.999270765

p_ni:  0.000729235

Data Source:  BioPlex

RNPS1

Tbio

Novelty:  0.03203224

p_int:  0.998543922

p_ni:  0.001456078

Score:  0.156

Data Source:  BioPlex,STRINGDB

ZNF16

Tbio

Family:  TF

Novelty:  0.18433365

p_int:  0.997666862

p_ni:  0.002236282

p_wrong:  0.000096856

Data Source:  BioPlex

AFF4

Tbio

Family:  TF

Novelty:  0.02113896

p_int:  0.995869207

p_ni:  0.004130663

p_wrong:  1.3e-7

Data Source:  BioPlex

MORF4L1

Tbio

Family:  Epigenetic

Novelty:  0.01696001

p_int:  0.994498723

p_ni:  0.005501277

Data Source:  BioPlex

MLLT3

Tchem

Novelty:  0.00361056

p_int:  0.994473848

p_ni:  0.00548597

p_wrong:  0.000040183

Data Source:  BioPlex

CLK3

Tchem

Family:  Kinase

Novelty:  0.03466191

p_int:  0.993289602

p_ni:  0.00670946

p_wrong:  9.38e-7

Data Source:  BioPlex

UBTF

Tbio

Family:  TF

Novelty:  0.00421069

p_int:  0.988442368

p_ni:  0.011557627

p_wrong:  5e-9

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Functions (1)

Components (2)

Processes (2)

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (11)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 11

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
IGF-1 measurement	EFO_0004627	1	3	3		92
glomerular filtration rate	EFO_0005208	2	2	2		78.7
atrial fibrillation	EFO_0000275	2	3	0	1.1	77.8
hemoglobin measurement	EFO_0004509	2	1	2		75.6
red blood cell density measurement	EFO_0007978	1	1	1		71.9

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 11

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
IGF-1 measurement	EFO_0004627	3		92
glomerular filtration rate	EFO_0005208	2		78.7
atrial fibrillation	EFO_0000275	0	1.1	77.8
hemoglobin measurement	EFO_0004509	2		75.6
red blood cell density measurement	EFO_0007978	1		71.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Cytoplasm
Differentiation
Metal-binding
Nucleus
Reference proteome
Spermatogenesis
Zinc
Zinc-finger

GWAS Trait Find Similar Targets

No Header	No Header
atrial fibrillation
body height
electrocardiography
glomerular filtration rate
hematocrit
hemoglobin measurement
IGF-1 measurement
red blood cell density measurement
red blood cell distribution width
reticulocyte count

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	ring finger protein 151		693744
Mouse	ring finger protein 151	MGI:1914754	67504
Rat	ring finger protein 151	RGD:1309302	302977
Dog	ring finger protein 151	VGNC:45640	611018
Horse	ring finger protein 151	VGNC:22446	100068047

Species	Name	OMA	EggNOG	Inparanoid
Macaque	ring finger protein 151
Mouse	ring finger protein 151
Rat	ring finger protein 151
Dog	ring finger protein 151
Horse	ring finger protein 151

Publication Statistics

PubMed Score 0.79

PubMed score by year

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Related Publications

Text Mined References (3)

Items per page:

10

0 of 0

PMID	Year	Title