You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
RNF149
E3 ubiquitin-protein ligase RNF149

Protein Summary
Description
E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295317
  • ENSP00000295317
  • ENSG00000163162

Symbol
  • DNAPTP2
  • DNAPTP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
cell type or tissue
0.8
transcription factor binding site profile
0.74
tissue sample
0.7
disease perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.43   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.43   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
LSMEM2
Tdark
Novelty:  43
p_int:  0.999828741
p_ni:  0.000171253
p_wrong:  5e-9
Data Source:  BioPlex
BTNL8
Tdark
Novelty:  0.40339869
p_int:  0.996144247
p_ni:  0.003855752
p_wrong:  1e-9
Data Source:  BioPlex
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.996128106
p_ni:  0.003871874
p_wrong:  2e-8
Data Source:  BioPlex
TNFRSF10B
Tbio
Novelty:  0.00054433
p_int:  0.995281553
p_ni:  0.004718447
p_wrong:  1e-9
Score:  0.726
Data Source:  BioPlex,STRINGDB
PCDHGB4
Tdark
Novelty:  0.25018904
p_int:  0.98694044
p_ni:  0.01305935
p_wrong:  2.1e-7
Data Source:  BioPlex
HFE
Tbio
Novelty:  0.00042077
p_int:  0.982638756
p_ni:  0.017361244
Data Source:  BioPlex
TNFRSF10A
Tchem
Novelty:  0.0003383
p_int:  0.953350751
p_ni:  0.046649244
p_wrong:  5e-9
Data Source:  BioPlex
MRAP2
Tbio
Novelty:  0.0420503
p_int:  0.945259489
p_ni:  0.054740508
p_wrong:  3e-9
Data Source:  BioPlex
P01911
Tchem
Novelty:  0.00240724
p_int:  0.943989575
p_ni:  0.056010387
p_wrong:  3.8e-8
Data Source:  BioPlex
TSPAN3
Tbio
Novelty:  0.06362133
p_int:  0.937638451
p_ni:  0.06215938
p_wrong:  0.000202169
Score:  0.228
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1
0
5.8
28.1
carotid artery intima media thickness
1
1
0
5.8
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
0
5.8
28.1
carotid artery intima media thickness
0
5.8
28.1
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 149
VGNC:356
459455
Mouse
MGI:2677438
67702
Rat
RGD:1308460
363222
Cow
ring finger protein 149
VGNC:34029
506267
Pig
ring finger protein 149
100519085
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 149
Mouse
Rat
Cow
ring finger protein 149
Pig
ring finger protein 149
Publication Statistics
PubMed Score 1.43
PubMed score by year
PubTator Score 1.46
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title