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Tbio
RNF146
E3 ubiquitin-protein ligase RNF146

Protein Summary
Description
E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'. May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective prote ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309649
  • ENSP00000309365
  • ENSG00000118518
  • ENST00000368314
  • ENSP00000357297
  • ENST00000608991
  • ENSP00000477168
  • ENST00000610153
  • ENSP00000476814
  • ENST00000616343
  • ENSP00000479890
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
cell type or tissue
0.8
tissue sample
0.73
transcription factor binding site profile
0.69
virus perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.77   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.77   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (112)
CHD1L
Tbio
Family:  Enzyme
Novelty:  0.00980287
p_int:  0.999999944
p_ni:  5.6e-8
Score:  0.855
Data Source:  BioPlex,STRINGDB
PARP2
Tclin
Family:  Enzyme
Novelty:  0.00545618
p_int:  0.999997098
p_ni:  0.000002902
Score:  0.797
Data Source:  BioPlex,STRINGDB
XPC
Tbio
Novelty:  0.00775175
p_int:  0.999892263
p_ni:  0.000107737
Score:  0.815
Data Source:  BioPlex,STRINGDB
LIG3
Tbio
Family:  Enzyme
Novelty:  0.00809038
p_int:  0.998491396
p_ni:  0.001508604
Score:  0.356
Data Source:  BioPlex,STRINGDB
SUPT16H
Tbio
Family:  Enzyme
Novelty:  0.01026868
p_int:  0.971560371
p_ni:  0.028439629
Score:  0.696
Data Source:  BioPlex,STRINGDB
SSRP1
Tbio
Family:  TF
Novelty:  0.0143993
p_int:  0.945214678
p_ni:  0.054785322
Score:  0.71
Data Source:  BioPlex,STRINGDB
PARP1
Tclin
Family:  Enzyme
Novelty:  0.00033016
p_int:  0.910715726
p_ni:  0.089284274
Score:  0.911
Data Source:  BioPlex,STRINGDB
CETN2
Tbio
Novelty:  0.00641301
p_int:  0.844865385
p_ni:  0.155134615
Score:  0.672
Data Source:  BioPlex,STRINGDB
TNKS
Tchem
Family:  Enzyme
Novelty:  0.00404545
Score:  0.987
Data Source:  Reactome,STRINGDB
AXIN1
Tbio
Novelty:  0.00175842
Score:  0.985
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Degradation of AXIN (R-HSA-4641257)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of AXIN
Reactome
Deubiquitination
Reactome
Intracellular signaling by second messengers
Reactome
Metabolism of proteins
Reactome
PIP3 activates AKT signaling
Name
Explore in Pharos
Explore in Source
Degradation of AXIN
Deubiquitination
Intracellular signaling by second messengers
Metabolism of proteins
PIP3 activates AKT signaling
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
4
5
10
98.8
waist-hip ratio
4
5
7
98.8
hip circumference
2
5
7
98.4
BMI-adjusted waist circumference
1
4
4
97.8
waist circumference
2
4
4
97.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
10
98.8
waist-hip ratio
7
98.8
hip circumference
7
98.4
BMI-adjusted waist circumference
4
97.8
waist circumference
4
97.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 146
VGNC:3684
462985
Macaque
ring finger protein 146
712152
Mouse
MGI:1915281
68031
Rat
RGD:1306482
308051
Dog
ring finger protein 146
VGNC:45638
476288
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 146
Macaque
ring finger protein 146
Mouse
Rat
Dog
ring finger protein 146
Publication Statistics
PubMed Score 20.77
PubMed score by year
PubTator Score 14.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title