Tbio RNF145 RING finger protein 145

Protein Summary

Description

E3 ubiquitin ligase that catalyzes the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. In response to bacterial infection, negatively regulates the phagocyte oxidative burst by controlling the turnover of the NADPH oxidase complex subunits. Promotes monoubiquitination of CYBA and 'Lys-48'-linked polyubiquitination and degradation of CYBB NADPH oxidase catalytic subunits, both essential for the generation of antimicrobial reactive oxygen species. Involved in the maintenance of cholesterol homeostasis. In response to high sterol concentrations ubiquitinates HMGCR, a rate-limiting enzyme in cholesterol biosynthesis, and targets it for degradation. The interaction with INSIG1 is required for this function. In addition, triggers ubiquitination of SCAP, likely inhibiting its transport to the Golgi apparatus and the subsequent processing/maturation of SREBPF2, ultimately downregulating cholesterol biosynthesis.

Uniprot Accession IDs

• Q96MT1
• B7Z903
• B7Z949
• E7EVI7
• Q8IVP7

Gene Name

• RNF145

Ensembl ID

• ENST00000274542
• ENSP00000274542
• ENSG00000145860
• ENST00000424310
• ENSP00000409064
• ENST00000518802
• ENSP00000430955
• ENST00000519865
• ENSP00000430397
• ENST00000520638
• ENSP00000429071
• ENST00000521606
• ENSP00000430753
• ENST00000611185
• ENSP00000482720

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
small molecule perturbation	0.84
transcription factor perturbation	0.84
transcription factor binding site profile	0.7
transcription factor	0.69
microRNA	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.89   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 83   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.89   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0