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Tbio
RNF145
RING finger protein 145

Protein Summary
Description
E3 ubiquitin ligase that catalyzes the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. In response to bacterial infection, negatively regulates the phagocyte oxidative burst by controlling the turnover of the NADPH oxidase complex subunits. Promotes monoubiquitination of CYBA and 'Lys-48'-linked polyubiquitination and degradation of CYBB NADPH oxidase catalytic subunits, both essential for the generation of antimicrobial reactive oxygen species. Involved in the maintenance of cholesterol homeostasis. In response to high sterol concentrations ubiquitinates HMGCR, a rate-limiting enzyme in cholesterol biosynthesis, and targets it for degradation. The interaction with INSIG1 is required for this function. In addition, triggers ubiquitination of SCAP, likely inhibiting its transport to the Golgi apparatus and the subsequent processing/maturation of SREBPF2, ultimately downregulating cholesterol biosynthesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274542
  • ENSP00000274542
  • ENSG00000145860
  • ENST00000424310
  • ENSP00000409064
  • ENST00000518802
  • ENSP00000430955
  • ENST00000519865
  • ENSP00000430397
  • ENST00000520638
  • ENSP00000429071
  • ENST00000521606
  • ENSP00000430753
  • ENST00000611185
  • ENSP00000482720
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.84
transcription factor perturbation
0.84
transcription factor binding site profile
0.7
transcription factor
0.69
microRNA
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.19   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.19   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
UBE2G2
Tbio
Novelty:  0.04298958
Score:  0.756
Data Source:  STRINGDB
AK3
Tbio
Family:  Kinase
Novelty:  0.02673466
Score:  0.742
Data Source:  STRINGDB
ARHGEF3
Tbio
Novelty:  0.02419137
Score:  0.721
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.72
Data Source:  STRINGDB
MARCH6
Tbio
Family:  Enzyme
Novelty:  0.01818691
Score:  0.662
Data Source:  STRINGDB
CST8
Tbio
Novelty:  0.02316886
Score:  0.661
Data Source:  STRINGDB
EHD3
Tbio
Novelty:  0.02008691
Score:  0.661
Data Source:  STRINGDB
RNFT1
Tdark
Novelty:  1.15288082
Score:  0.658
Data Source:  STRINGDB
JMJD1C
Tbio
Family:  Epigenetic
Novelty:  0.02919389
Score:  0.651
Data Source:  STRINGDB
PALMD
Tbio
Novelty:  0.11193793
Score:  0.623
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
3
4
97.9
platelet count
2
2
2
88.2
3
2
0
1.4
81.7
1
2
0
1.4
81
alkaline phosphatase measurement
2
1
1
5.6
66.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
97.9
platelet count
2
88.2
0
1.4
81.7
0
1.4
81
alkaline phosphatase measurement
1
5.6
66.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 145
VGNC:4151
462230
Macaque
ring finger protein 145
694354
Mouse
MGI:1921565
74315
Rat
RGD:1309561
287212
Dog
ring finger protein 145
VGNC:45637
489154
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 145
Macaque
ring finger protein 145
Mouse
Rat
Dog
ring finger protein 145
Publication Statistics
PubMed Score 6.19
PubMed score by year
PubTator Score 0.95
PubTator score by year
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Related Publications
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PMID
Year
Title