RNF145
RING finger protein 145
Protein Summary
E3 ubiquitin ligase that catalyzes the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. In response to bacterial infection, negatively regulates the phagocyte oxidative burst by controlling the turnover of the NADPH oxidase complex subunits. Promotes monoubiquitination of CYBA and 'Lys-48'-linked polyubiquitination and degradation of CYBB NADPH oxidase catalytic subunits, both essential for the generation of antimicrobial reactive oxygen species. Involved in the maintenance of cholesterol homeostasis. In response to high sterol concentrations ubiquitinates HMGCR, a rate-limiting enzyme in cholesterol biosynthesis, and targets it for degradation. The interaction with INSIG1 is required for this function. In addition, triggers ubiquitination of SCAP, likely inhibiting its transport to the Golgi apparatus and the subsequent processing/maturation of SREBPF2, ultimately downregulating cholesterol biosynthesis.
- ENST00000274542
- ENSP00000274542
- ENSG00000145860
- ENST00000424310
- ENSP00000409064
- ENST00000518802
- ENSP00000430955
- ENST00000519865
- ENSP00000430397
- ENST00000520638
- ENSP00000429071
- ENST00000521606
- ENSP00000430753
- ENST00000611185
- ENSP00000482720
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
small molecule perturbation | 0.84 | ||
transcription factor perturbation | 0.84 | ||
transcription factor binding site profile | 0.7 | ||
transcription factor | 0.69 | ||
microRNA | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.19 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 83 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.19 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 83 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (64)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (4)
Functions (2)
Components (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 4 | 3 | 4 | 97.9 | |||||
platelet count | 2 | 2 | 2 | 88.2 | |||||
3 | 2 | 0 | 1.4 | 81.7 | |||||
1 | 2 | 0 | 1.4 | 81 | |||||
alkaline phosphatase measurement | 2 | 1 | 1 | 5.6 | 66.8 | ||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 4 | 97.9 | |||||
platelet count | 2 | 88.2 | |||||
0 | 1.4 | 81.7 | |||||
0 | 1.4 | 81 | |||||
alkaline phosphatase measurement | 1 | 5.6 | 66.8 | ||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ring finger protein 145 | VGNC:4151 | 462230 | |||||
Macaque | ring finger protein 145 | 694354 | ||||||
Mouse | MGI:1921565 | 74315 | ||||||
Rat | RGD:1309561 | 287212 | ||||||
Dog | ring finger protein 145 | VGNC:45637 | 489154 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ring finger protein 145 | |||||
Macaque | ring finger protein 145 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ring finger protein 145 | |||||
Publication Statistics
PubMed Score 6.19
PubMed score by year
PubTator Score 0.95
PubTator score by year
Related Publications
Text Mined References (6)
Items per page:
0 of 0
PMID | Year | Title |
|---|