Tbio RNF141 RING finger protein 141

Protein Summary

Description

May be involved in spermatogenesis. The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. Abundant expression of this gene was found in the testicular tissue of fertile men, but was not detected in azoospermic patients. Studies of the mouse counterpart suggest that this gene may function as a testis specific transcription factor during spermatogenesis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8WVD5
• A8K149
• Q9NZB4

Gene Name

• RNF141

Ensembl ID

• ENST00000265981
• ENSP00000265981
• ENSG00000110315

Symbol

• ZNF230
• ZFP26
• RFP141
• ZNF230

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.93
transcription factor perturbation	0.88
transcription factor binding site profile	0.83
virus perturbation	0.83
histone modification site profile	0.82

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.72   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 187   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.72   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0