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Tdark
RNF130
E3 ubiquitin-protein ligase RNF130

Protein Summary
Description
May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin-protein ligase. The protein encoded by this gene contains a RING finger motif and is similar to g1, a Drosophila zinc-finger protein that is expressed in mesoderm and involved in embryonic development. The expression of the mouse counterpart was found to be upregulated in myeloblastic cells following IL3 deprivation, suggesting that this gene may regulate growth factor withdrawal-induced apoptosis of myeloid precursor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261947
  • ENSP00000261947
  • ENSG00000113269
  • ENST00000521389
  • ENSP00000430237

Symbol
  • GP
  • G1RZFP
  • GOLIATH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
transcription factor perturbation
0.88
disease perturbation
0.79
interacting protein
0.78
tissue sample
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.61   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.61   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (307)
MCOLN3
Tchem
Family:  IC
Novelty:  0.03209262
p_int:  0.996235761
p_ni:  0.003764239
Data Source:  BioPlex
BTNL8
Tdark
Novelty:  0.40339869
p_int:  0.949666448
p_ni:  0.050333552
Score:  0.175
Data Source:  BioPlex,STRINGDB
PTCH1
Tbio
Novelty:  0.00077635
p_int:  0.942554689
p_ni:  0.05743093
p_wrong:  0.00001438
Data Source:  BioPlex
SCGB1D4
Tdark
Novelty:  0.15597658
p_int:  0.904140643
p_ni:  0.095843479
p_wrong:  0.000015878
Score:  0.17
Data Source:  BioPlex,STRINGDB
PON2
Tbio
Family:  Enzyme
Novelty:  0.00414855
p_int:  0.896597858
p_ni:  0.103401995
p_wrong:  1.47e-7
Score:  0.155
Data Source:  BioPlex,STRINGDB
GGT7
Tbio
Family:  Enzyme
Novelty:  0.01374716
p_int:  0.877078077
p_ni:  0.12289232
p_wrong:  0.000029603
Score:  0.175
Data Source:  BioPlex,STRINGDB
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.818775389
p_ni:  0.181171149
p_wrong:  0.000053462
Data Source:  BioPlex
CHRNB4
Tclin
Family:  IC
Novelty:  0.01151716
p_int:  0.81145091
p_ni:  0.132219092
p_wrong:  0.056329999
Data Source:  BioPlex
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.757278909
p_ni:  0.242721066
p_wrong:  2.5e-8
Data Source:  BioPlex
MKRN1
Tbio
Family:  Enzyme
Novelty:  0.04485183
Score:  0.962
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
1
1
82.4
monocyte percentage of leukocytes
1
1
1
70.4
viral load
1
1
1
68.5
systolic blood pressure
1
1
1
62.7
peak expiratory flow
1
1
1
58.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
82.4
monocyte percentage of leukocytes
1
70.4
viral load
1
68.5
systolic blood pressure
1
62.7
peak expiratory flow
1
58.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 130
VGNC:4149
741135
Macaque
ring finger protein 130
715356
Mouse
MGI:1891717
59044
Dog
ring finger protein 130
VGNC:45630
474651
Horse
ring finger protein 130
VGNC:22434
100067162
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 130
Macaque
ring finger protein 130
Mouse
Dog
ring finger protein 130
Horse
ring finger protein 130
Publication Statistics
PubMed Score 4.61
PubMed score by year
PubTator Score 4.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title