Tbio RNF13 E3 ubiquitin-protein ligase RNF13

Protein Summary

Description

E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. The specific function of this gene has not yet been determined. Alternatively spliced transcript variants that encode the same protein have been reported. A pseudogene, which is also located on chromosome 3, has been defined for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O43567
• A6NC87
• B3KR12
• Q05D66
• Q6IBJ9

Gene Name

• RNF13

Ensembl ID

• ENST00000344229
• ENSP00000341361
• ENSG00000082996
• ENST00000361785
• ENSP00000355268
• ENST00000392894
• ENSP00000376628

Symbol

• RZF
• RZF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.84
transcription factor perturbation	0.84
transcription factor binding site profile	0.81
transcription factor	0.7
disease perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.46   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 120   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.46   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0