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Tbio
RNF13
E3 ubiquitin-protein ligase RNF13

Protein Summary
Description
E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. The specific function of this gene has not yet been determined. Alternatively spliced transcript variants that encode the same protein have been reported. A pseudogene, which is also located on chromosome 3, has been defined for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344229
  • ENSP00000341361
  • ENSG00000082996
  • ENST00000361785
  • ENSP00000355268
  • ENST00000392894
  • ENSP00000376628

Symbol
  • RZF
  • RZF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
transcription factor perturbation
0.84
transcription factor binding site profile
0.81
transcription factor
0.7
disease perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.61   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.61   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
AP3S2
Tdark
Novelty:  0.25186243
p_int:  0.999997344
p_ni:  0.000002633
p_wrong:  2.4e-8
Score:  0.234
Data Source:  BioPlex,STRINGDB
AP3S1
Tbio
Novelty:  0.12425009
p_int:  0.999927299
p_ni:  0.000072701
Score:  0.215
Data Source:  BioPlex,STRINGDB
TYK2
Tclin
Family:  Kinase
Novelty:  0.00237955
p_int:  0.999706444
p_ni:  0.000293555
Data Source:  BioPlex
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.998995447
p_ni:  0.00100455
p_wrong:  3e-9
Data Source:  BioPlex
AP3D1
Tbio
Novelty:  0.04425592
p_int:  0.998617223
p_ni:  0.001382777
Score:  0.534
Data Source:  BioPlex,STRINGDB
CLEC11A
Tbio
Novelty:  0.03060601
p_int:  0.997292756
p_ni:  0.002707244
Data Source:  BioPlex
HPSE2
Tbio
Family:  Enzyme
Novelty:  0.00583615
p_int:  0.992601695
p_ni:  0.004843304
p_wrong:  0.002555002
Data Source:  BioPlex
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.990752379
p_ni:  0.009247599
p_wrong:  2.2e-8
Data Source:  BioPlex
LGALS9
Tchem
Novelty:  0.00381766
p_int:  0.989684116
p_ni:  0.010227821
p_wrong:  0.000088063
Data Source:  BioPlex
TSPAN3
Tbio
Novelty:  0.06362133
p_int:  0.987177106
p_ni:  0.012790337
p_wrong:  0.000032557
Score:  0.186
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
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Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
1
2
53.3
1
1
0
1.5
50.6
pulse pressure measurement
1
1
1
45.2
diet measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
53.3
0
1.5
50.6
pulse pressure measurement
1
45.2
diet measurement
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 13
VGNC:2538
460776
Macaque
ring finger protein 13
711339
Mouse
MGI:1346341
24017
Rat
RGD:1594062
681578
Dog
ring finger protein 13
VGNC:45629
477109
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 13
Macaque
ring finger protein 13
Mouse
Rat
Dog
ring finger protein 13
Publication Statistics
PubMed Score 13.61
PubMed score by year
PubTator Score 6.41
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title