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Tbio
RNF126
E3 ubiquitin-protein ligase RNF126

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins (PubMed:23277564, PubMed:24275455, PubMed:24981174). Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates (By similarity). Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome (PubMed:24981174, PubMed:29042515). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination (PubMed:23418353). By ubiquitinating CDKN1A/p21 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292363
  • ENSP00000292363
  • ENSG00000070423
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.76
transcription factor binding site profile
0.72
tissue sample
0.71
cell type or tissue
0.63
molecular function
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.95   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.95   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (312)
UBB
Tbio
Novelty:  0.00661254
p_int:  0.999996673
p_ni:  0.000003327
Score:  0.932
Data Source:  BioPlex,STRINGDB
MINDY1
Tbio
Novelty:  0.31540765
p_int:  0.999955593
p_ni:  0.000044407
Score:  0.227
Data Source:  BioPlex,STRINGDB
TAX1BP1
Tbio
Novelty:  0.02498501
p_int:  0.999906124
p_ni:  0.000093876
Score:  0.216
Data Source:  BioPlex,STRINGDB
CAPN15
Tbio
Novelty:  0.01046841
p_int:  0.998647221
p_ni:  0.00135277
p_wrong:  8e-9
Score:  0.254
Data Source:  BioPlex,STRINGDB
CRYM
Tbio
Family:  Enzyme
Novelty:  0.02044871
p_int:  0.995713107
p_ni:  0.004286893
Score:  0.403
Data Source:  BioPlex,STRINGDB
KIAA0100
Tbio
Novelty:  0.10510857
p_int:  0.995310898
p_ni:  0.004239451
p_wrong:  0.000449651
Score:  0.27
Data Source:  BioPlex,STRINGDB
SCN1B
Tbio
Family:  IC
Novelty:  0.00910273
p_int:  0.993295094
p_ni:  0.006703219
p_wrong:  0.000001687
Data Source:  BioPlex
BAG6
Tbio
Novelty:  0.0035578
p_int:  0.988185933
p_ni:  0.011814067
Score:  0.969
Data Source:  BioPlex,STRINGDB
GET4
Tbio
Novelty:  0.03516005
p_int:  0.986359883
p_ni:  0.013640117
Score:  0.873
Data Source:  BioPlex,STRINGDB
SKP2
Tbio
Family:  Enzyme
Novelty:  0.00182658
p_int:  0.98404413
p_ni:  0.015955867
p_wrong:  3e-9
Score:  0.916
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
worry measurement
2
2
1
5.8
47.5
sex hormone-binding globulin measurement
3
2
3
41.9
cognitive function measurement
2
1
2
31.4
mathematical ability
1
1
1
21.5
pulse pressure measurement
1
1
1
14
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
worry measurement
1
5.8
47.5
sex hormone-binding globulin measurement
3
41.9
cognitive function measurement
2
31.4
mathematical ability
1
21.5
pulse pressure measurement
1
14
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 126
740610
Macaque
ring finger protein 126
702842
Mouse
MGI:1917544
70294
Rat
RGD:1306011
314613
Dog
ring finger protein 126 [Source:HGNC Symbol;Acc:HGNC:21151]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 126
Macaque
ring finger protein 126
Mouse
Rat
Dog
ring finger protein 126 [Source:HGNC Symbol;Acc:HGNC:21151]
Publication Statistics
PubMed Score 18.95
PubMed score by year
PubTator Score 5.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title