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Tbio
RNF123
E3 ubiquitin-protein ligase RNF123

Protein Summary
Description
Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle. The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
histone modification site profile
0.72
tissue sample
0.65
cell line
0.63
transcription factor binding site profile
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.77   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.77   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (340)
UBAC1
Tbio
Novelty:  0.00122518
p_int:  0.999979969
p_ni:  0.000020031
Score:  0.997
Data Source:  BioPlex,STRINGDB
IGF2
Tbio
Novelty:  0.00021277
p_int:  0.999967108
p_ni:  0.000032892
Data Source:  BioPlex
NMB
Tbio
Novelty:  0.00729571
p_int:  0.999196716
p_ni:  0.000803284
Data Source:  BioPlex
BVES
Tbio
Novelty:  0.02309912
p_int:  0.99874855
p_ni:  0.00125145
Score:  0.808
Data Source:  BioPlex,STRINGDB
ELAC2
Tbio
Family:  Enzyme
Novelty:  0.01234318
p_int:  0.998163112
p_ni:  0.001836888
Score:  0.586
Data Source:  BioPlex,STRINGDB
INSL6
Tdark
Novelty:  0.06986187
p_int:  0.997061259
p_ni:  0.002938741
Data Source:  BioPlex
AKIRIN2
Tbio
Novelty:  0.04603317
p_int:  0.995114965
p_ni:  0.004885035
Score:  0.216
Data Source:  BioPlex,STRINGDB
GREM2
Tbio
Novelty:  0.01839564
p_int:  0.994757087
p_ni:  0.005242913
Data Source:  BioPlex
USP48
Tbio
Family:  Enzyme
Novelty:  0.10103618
p_int:  0.99435117
p_ni:  0.00564883
Score:  0.575
Data Source:  BioPlex,STRINGDB
MAP3K6
Tchem
Family:  Kinase
Novelty:  0.03743265
p_int:  0.981882436
p_ni:  0.018117564
Score:  0.333
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Deubiquitination
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Deubiquitination
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (39)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
5
6
5
8.2
98.9
mathematical ability
4
5
6
98.5
reticulocyte count
2
3
3
96.4
intelligence
4
8
3
7.4
96.1
household income
2
5
6
93.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
5
8.2
98.9
mathematical ability
6
98.5
reticulocyte count
3
96.4
intelligence
3
7.4
96.1
household income
6
93.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ring finger protein 123
705340
Mouse
MGI:2148796
84585
Rat
RGD:2301394
100190936
Dog
ring finger protein 123
VGNC:45626
484767
Horse
ring finger protein 123
VGNC:22430
100053010
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ring finger protein 123
Mouse
Rat
Dog
ring finger protein 123
Horse
ring finger protein 123
Publication Statistics
PubMed Score 52.77
PubMed score by year
PubTator Score 12.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title