You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RNF10
RING finger protein 10

Protein Summary
Description
Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination. The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325954
  • ENSP00000322242
  • ENSG00000022840
  • ENST00000413266
  • ENSP00000415682

Symbol
  • KIAA0262
  • RIE2
  • RIE2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
cell type or tissue
0.81
biological process
0.74
transcription factor perturbation
0.74
cell line
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.4   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.4   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
UBE2E3
Tbio
Novelty:  0.03477232
p_int:  1
Score:  0.341
Data Source:  BioPlex,STRINGDB
UBE2D4
Tbio
Novelty:  0.40836104
p_int:  0.999999268
p_ni:  7.23e-7
p_wrong:  9e-9
Score:  0.215
Data Source:  BioPlex,STRINGDB
UBE2D1
Tbio
Novelty:  0.00865867
p_int:  0.999999235
p_ni:  7.64e-7
p_wrong:  1e-9
Score:  0.247
Data Source:  BioPlex,STRINGDB
HAUS2
Tbio
Novelty:  0.49903382
p_int:  0.999989455
p_ni:  0.000010466
p_wrong:  7.9e-8
Data Source:  BioPlex
TBCCD1
Tbio
Novelty:  0.21991508
p_int:  0.99995036
p_ni:  0.000041839
p_wrong:  0.000007801
Data Source:  BioPlex
UBE2D2
Tbio
Novelty:  0.00603877
p_int:  0.999942151
p_ni:  0.000006294
p_wrong:  0.000051556
Score:  0.421
Data Source:  BioPlex,STRINGDB
TRIM26
Tbio
Novelty:  0.07177119
p_int:  0.999915736
p_ni:  0.000084263
Data Source:  BioPlex
HAUS3
Tbio
Novelty:  0.00398858
p_int:  0.999873037
p_ni:  0.000125029
p_wrong:  0.000001934
Data Source:  BioPlex
PPP2R3B
Tbio
Family:  Enzyme
Novelty:  0.02932064
p_int:  0.999828011
p_ni:  0.000171936
p_wrong:  5.3e-8
Data Source:  BioPlex
NCOA4
Tbio
Novelty:  0.00487453
p_int:  0.999637984
p_ni:  0.00013658
p_wrong:  0.000225436
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
8
12
99
C-reactive protein measurement
2
10
11
98
serum gamma-glutamyl transferase measurement
1
6
6
96.5
reticulocyte measurement
3
3
6
93.7
mean reticulocyte volume
1
2
2
90.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
12
99
C-reactive protein measurement
11
98
serum gamma-glutamyl transferase measurement
6
96.5
reticulocyte measurement
6
93.7
mean reticulocyte volume
2
90.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 10
VGNC:5573
452308
Macaque
ring finger protein 10
697428
Mouse
MGI:1859162
50849
Rat
RGD:1309282
288710
Dog
ring finger protein 10
477514
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 10
Macaque
ring finger protein 10
Mouse
Rat
Dog
ring finger protein 10
Publication Statistics
PubMed Score 14.40
PubMed score by year
PubTator Score 5.13
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title