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Tbio
RND2
Rho-related GTP-binding protein RhoN

Protein Summary
Description
May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity). This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin cytoskeleton organization in response to extracellular growth factors. This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking. The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000587250
  • ENSP00000466680
  • ENSG00000108830

Symbol
  • ARHN
  • RHO7
  • ARHN
  • RHO7
  • RhoN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
virus perturbation
0.76
transcription factor binding site profile
0.71
PubMedID
0.68
histone modification site profile
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.67   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.67   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (95)
USP47
Tchem
Family:  Enzyme
Novelty:  0.07579226
p_int:  0.897405414
p_ni:  0.102594586
Score:  0.223
Data Source:  BioPlex,STRINGDB
RRAS
Tbio
Family:  Enzyme
Novelty:  0.00786502
Score:  0.952
Data Source:  STRINGDB
PLXND1
Tbio
Novelty:  0.01249713
Score:  0.941
Data Source:  STRINGDB
SEMA3E
Tbio
Novelty:  0.00936004
Score:  0.935
Data Source:  STRINGDB
ARHGAP35
Tbio
Family:  Enzyme
Novelty:  0.00970784
Score:  0.804
Data Source:  STRINGDB
WAS
Tbio
Novelty:  0.00087362
Score:  0.732
Data Source:  STRINGDB
ARHGEF28
Tbio
Novelty:  0.01856808
Score:  0.69
Data Source:  STRINGDB
WASL
Tbio
Novelty:  0.0029314
Score:  0.689
Data Source:  STRINGDB
ITSN1
Tbio
Novelty:  0.01327346
Score:  0.687
Data Source:  STRINGDB
MCF2
Tbio
Novelty:  0.00345951
Score:  0.683
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Integrin signalling pathway
PathwayCommons: pid
Plexin-D1 Signaling
Name
Explore in Pharos
Explore in Source
Integrin signalling pathway
Plexin-D1 Signaling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
87.8
myeloid white cell count
1
1
1
71.9
leukocyte count
1
1
1
55.2
aspartate aminotransferase measurement
1
1
0
7.1
55.2
age at menopause
1
1
1
45.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
87.8
myeloid white cell count
1
71.9
leukocyte count
1
55.2
aspartate aminotransferase measurement
0
7.1
55.2
age at menopause
1
45.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
Rho family GTPase 2
712559
Mouse
MGI:1338755
11858
Rat
RGD:1306172
303553
Dog
Rho family GTPase 2
VGNC:45617
100855472
Horse
Rho family GTPase 2 [Source:HGNC Symbol;Acc:HGNC:18315]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
Rho family GTPase 2
Mouse
Rat
Dog
Rho family GTPase 2
Horse
Rho family GTPase 2 [Source:HGNC Symbol;Acc:HGNC:18315]
Publication Statistics
PubMed Score 61.67
PubMed score by year
PubTator Score 19.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title