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Tbio
RNASET2
Ribonuclease T2

Protein Summary
Description
Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism. This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000421787
  • ENSP00000390833
  • ENSG00000026297
  • ENST00000476238
  • ENSP00000422846
  • ENST00000508775
  • ENSP00000426455

Symbol
  • RNASE6PL
  • RNASE6PL
  • bA514O12.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
virus perturbation
0.88
kinase perturbation
0.81
histone modification site profile
0.71
cellular component
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.06   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.06   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (121)
PDIA5
Tbio
Family:  Enzyme
Novelty:  0.06234465
p_int:  0.987894056
p_ni:  0.012105944
Score:  0.319
Data Source:  BioPlex,STRINGDB
FBXO2
Tbio
Novelty:  0.01578361
p_int:  0.976842145
p_ni:  0.023157684
p_wrong:  1.71e-7
Score:  0.241
Data Source:  BioPlex,STRINGDB
RNASE2
Tchem
Family:  Enzyme
Novelty:  0.00267471
Score:  0.953
Data Source:  STRINGDB
RNASE3
Tbio
Family:  Enzyme
Novelty:  0.00059878
Score:  0.948
Data Source:  STRINGDB
NPC2
Tbio
Novelty:  0.00342898
Score:  0.931
Data Source:  STRINGDB
C6orf120
Tdark
Novelty:  0.90888293
Score:  0.928
Data Source:  STRINGDB
ADA2
Tbio
Family:  Enzyme
Novelty:  0.01077582
Score:  0.926
Data Source:  STRINGDB
CTSA
Tchem
Family:  Enzyme
Novelty:  0.00170931
Score:  0.924
Data Source:  STRINGDB
CREG1
Tbio
Novelty:  0.0071867
Score:  0.921
Data Source:  STRINGDB
FUCA1
Tchem
Family:  Enzyme
Novelty:  0.00961721
Score:  0.915
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
0
1.2
96.3
2
2
0
1.2
92.8
autoimmune thyroid disease
1
1
0
1.1
87.8
3
2
1
1.1
83.3
Thyroid preparation use measurement
2
3
3
82.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
96.3
0
1.2
92.8
autoimmune thyroid disease
0
1.1
87.8
1
1.1
83.3
Thyroid preparation use measurement
3
82.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribonuclease T2
VGNC:11212
736033
Macaque
ribonuclease T2
706533
Mouse
MGI:3702087
68195
Dog
ribonuclease T2
612451
Cow
ribonuclease T2
508245
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribonuclease T2
Macaque
ribonuclease T2
Mouse
Dog
ribonuclease T2
Cow
ribonuclease T2
Publication Statistics
PubMed Score 74.06
PubMed score by year
PubTator Score 76.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title