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Tchem
RNASEH1
Ribonuclease H1

Protein Summary
Description
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids (PubMed:10497183). Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II (PubMed:21700224). This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and plays a key role in DNA replication and repair. Alternate in-frame start codon initiation results in the production of alternate isoforms that are directed to the mitochondria or to the nucleus. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF). Mutations in this gene have been found in individuals with progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2. Alternative splicing results in additional coding and non-coding transcript variants. Pseudogenes of this gene have been defined on chromosomes 2 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315212
  • ENSP00000313350
  • ENSG00000171865

Symbol
  • RNH1
  • RNH1
  • H1RNA
  • PEOB2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
histone modification site profile
0.92
transcription factor perturbation
0.84
disease perturbation
0.83
transcription factor binding site profile
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.87   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.87   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (104)
CLEC3A
Tdark
Novelty:  0.21498836
p_int:  0.999998819
p_ni:  2.7e-8
p_wrong:  0.000001154
Score:  0.19
Data Source:  BioPlex,STRINGDB
SERPINF2
Tbio
Novelty:  0.00054719
p_int:  0.999995035
p_ni:  0.000004965
Data Source:  BioPlex
UACA
Tbio
Novelty:  0.05853699
p_int:  0.999991325
p_ni:  0.000008675
Data Source:  BioPlex
RBM26
Tdark
Novelty:  0.26601554
p_int:  0.999958108
p_ni:  0.000041892
Data Source:  BioPlex
RBM27
Tdark
Novelty:  0.04875536
p_int:  0.999915822
p_ni:  0.000084178
Data Source:  BioPlex
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.999914859
p_ni:  0.000006494
p_wrong:  0.000078646
Score:  0.187
Data Source:  BioPlex,STRINGDB
ECM1
Tbio
Novelty:  0.00518679
p_int:  0.99985925
p_ni:  0.000140739
p_wrong:  1.1e-8
Data Source:  BioPlex
CACTIN
Tbio
Novelty:  0.03222124
p_int:  0.999798518
p_ni:  0.00020147
p_wrong:  1.2e-8
Data Source:  BioPlex
CMAS
Tbio
Family:  Enzyme
Novelty:  0.04295627
p_int:  0.999573554
p_ni:  0.000426446
Data Source:  BioPlex
SCAF11
Tdark
Novelty:  0.00802779
p_int:  0.999339278
p_ni:  0.000659716
p_wrong:  0.000001006
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
2
2
82.9
low density lipoprotein cholesterol measurement
4
4
4
78.2
high density lipoprotein cholesterol measurement
3
2
3
77.8
apolipoprotein A 1 measurement
2
2
2
75
viral load
1
1
1
67.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
82.9
low density lipoprotein cholesterol measurement
4
78.2
high density lipoprotein cholesterol measurement
3
77.8
apolipoprotein A 1 measurement
2
75
viral load
1
67.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribonuclease H1
VGNC:354
743012
Macaque
ribonuclease H1
707122
Mouse
MGI:1335073
19819
Rat
RGD:1309012
298933
Dog
ribonuclease H1
475648
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribonuclease H1
Macaque
ribonuclease H1
Mouse
Rat
Dog
ribonuclease H1
Publication Statistics
PubMed Score 55.87
PubMed score by year
PubTator Score 75.70
PubTator score by year
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Related Publications
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PMID
Year
Title