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Tbio
RNASE7
Ribonuclease 7

Protein Summary
Description
Exhibits a potent RNase activity (PubMed:12244054, PubMed:12527768, PubMed:17150966). Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium (PubMed:12244054, PubMed:12527768, PubMed:25075772, PubMed:17150966). Causes loss of bacterial membrane integrity (PubMed:17150966). Probably contributes to urinary tract sterility (PubMed:25075772). Bactericidal activity is independent of RNase activity (PubMed:17150966). The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein has broad-spectrum antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298690
  • ENSP00000298690
  • ENSG00000165799
  • ENST00000481538
  • ENSP00000431382

Symbol
  • RAE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.57
molecular function
0.56
tissue
0.45
biological term
0.41
protein domain
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.86   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 59   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.86   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
SLCO6A1
Tbio
Family:  Transporter
Novelty:  0.07836028
p_int:  0.999114134
p_ni:  0.000770156
p_wrong:  0.000115711
Data Source:  BioPlex
ZIC1
Tbio
Family:  TF
Novelty:  0.00491601
p_int:  0.998306494
p_ni:  0.001693343
p_wrong:  1.63e-7
Data Source:  BioPlex
ZSCAN12
Tdark
Family:  TF
Novelty:  0.33578207
p_int:  0.997981155
p_ni:  0.00201866
p_wrong:  1.85e-7
Data Source:  BioPlex
TEFM
Tbio
Novelty:  0.10836617
p_int:  0.997924645
p_ni:  0.002016359
p_wrong:  0.000058997
Data Source:  BioPlex
EHBP1
Tbio
Novelty:  0.0656858
p_int:  0.996033844
p_ni:  0.003966092
p_wrong:  6.4e-8
Data Source:  BioPlex
GMCL1
Tbio
Novelty:  0.1543762
p_int:  0.99358236
p_ni:  0.006415448
p_wrong:  0.000002191
Data Source:  BioPlex
DPPA4
Tbio
Novelty:  0.05764302
p_int:  0.992728516
p_ni:  0.007268218
p_wrong:  0.000003266
Data Source:  BioPlex
B3GALNT1
Tbio
Family:  Enzyme
Novelty:  0.01235828
p_int:  0.988188248
p_ni:  0.011811747
p_wrong:  5e-9
Data Source:  BioPlex
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.977861041
p_ni:  0.022137167
p_wrong:  0.000001792
Data Source:  BioPlex
CCDC88C
Tbio
Novelty:  0.0495648
p_int:  0.97590748
p_ni:  0.02409077
p_wrong:  0.00000175
Score:  0.189
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
1
3
77.1
testosterone measurement
2
1
2
76.3
hemoglobin measurement
2
1
2
74.8
red blood cell density measurement
1
1
1
69.4
platelet crit
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
77.1
testosterone measurement
2
76.3
hemoglobin measurement
2
74.8
red blood cell density measurement
1
69.4
platelet crit
1
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Horse
ribonuclease 7
100072707
Cow
ribonuclease, RNase A family, 7
538679
Species
Name
OMA
EggNOG
Inparanoid
Horse
ribonuclease 7
Cow
ribonuclease, RNase A family, 7
Publication Statistics
PubMed Score 59.86
PubMed score by year
PubTator Score 58.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title