You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RNASE6
Ribonuclease K6

Protein Summary
Description
Ribonuclease which shows a preference for the pyrimidines uridine and cytosine (PubMed:8836175, PubMed:27013146). Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (PubMed:25075772, PubMed:27089320). Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (PubMed:27089320). Probably contributes to urinary tract sterility (PubMed:25075772). Bactericidal activity is independent of RNase activity (PubMed:27089320). The protein encoded by this gene is a member of the ribonuclease A superfamily and functions in the urinary tract. The protein has broad-spectrum antimicrobial activity against pathogenic bacteria. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304677
  • ENSP00000302046
  • ENSG00000169413

Symbol
  • RNS6
  • RAD1
  • RNS6
  • RNasek6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.76
tissue sample
0.64
gene perturbation
0.59
cell type or tissue
0.54
cell line
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.48   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.48   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
LY86
Tbio
Novelty:  0.00314575
Score:  0.787
Data Source:  STRINGDB
RNASET2
Tbio
Family:  Enzyme
Novelty:  0.01939252
Score:  0.781
Data Source:  STRINGDB
FCER1A
Tbio
Novelty:  0.00362182
Score:  0.728
Data Source:  STRINGDB
FCER1G
Tbio
Novelty:  0.00783146
Score:  0.711
Data Source:  STRINGDB
EPX
Tchem
Family:  Enzyme
Novelty:  0.00339273
Score:  0.699
Data Source:  STRINGDB
RNASE13
Tbio
Family:  Enzyme
Novelty:  0.05907604
Score:  0.661
Data Source:  STRINGDB
IL4R
Tclin
Novelty:  0.00359183
Score:  0.639
Data Source:  STRINGDB
LAPTM5
Tbio
Novelty:  0.06809459
Score:  0.639
Data Source:  STRINGDB
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.637
Data Source:  STRINGDB
MS4A6A
Tbio
Novelty:  0.04742307
Score:  0.613
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribonuclease A family member k6
VGNC:6796
473324
Macaque
ribonuclease A family member k6
704579
Mouse
MGI:1925666
78416
Rat
RGD:1303020
305842
Horse
ribonuclease A family member k6
VGNC:22416
100629897
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribonuclease A family member k6
Macaque
ribonuclease A family member k6
Mouse
Rat
Horse
ribonuclease A family member k6
Publication Statistics
PubMed Score 16.48
PubMed score by year
PubTator Score 8.03
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title