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Tbio
RNASE3
Eosinophil cationic protein

Protein Summary
Description
Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content. The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304639
  • ENSP00000302324
  • ENSG00000169397

Symbol
  • ECP
  • RNS3
  • ECP
  • RAF1
  • RNS3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.81
phenotype
0.57
tissue
0.54
disease
0.52
chemical
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1512.11   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 279   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1512.11   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 279   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (152)
POTEI
Tdark
Novelty:  0.41311202
p_int:  0.999998197
p_ni:  0.000001801
p_wrong:  2e-9
Data Source:  BioPlex
RNH1
Tbio
Family:  Enzyme
Novelty:  0.00307468
p_int:  0.999745724
p_ni:  0.000254276
Score:  0.428
Data Source:  BioPlex,STRINGDB
GTPBP2
Tbio
Novelty:  0.10282876
p_int:  0.999515577
p_ni:  0.000388018
p_wrong:  0.000096404
Score:  0.169
Data Source:  BioPlex,STRINGDB
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.996223881
p_ni:  0.003776119
Data Source:  BioPlex
ACTA2
Tbio
Novelty:  0.00199354
p_int:  0.994297885
p_ni:  0.005702115
Data Source:  BioPlex
BLK
Tchem
Family:  Kinase
Novelty:  0.00480349
p_int:  0.990025375
p_ni:  0.001106052
p_wrong:  0.008868573
Score:  0.189
Data Source:  BioPlex,STRINGDB
ACTB
Tbio
Novelty:  0.00006048
p_int:  0.965574362
p_ni:  0.034425638
Data Source:  BioPlex
GNAZ
Tbio
Novelty:  0.02008523
p_int:  0.947182046
p_ni:  0.052695632
p_wrong:  0.000122322
Score:  0.185
Data Source:  BioPlex,STRINGDB
GGPS1
Tchem
Family:  Enzyme
Novelty:  0.00292258
p_int:  0.92703456
p_ni:  0.07296544
Score:  0.161
Data Source:  BioPlex,STRINGDB
UBAC1
Tbio
Novelty:  0.00122518
p_int:  0.913516927
p_ni:  0.086483073
Score:  0.19
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Antimicrobial peptides (R-HSA-6803157)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil cationic protein measurement
1
1
1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil cationic protein measurement
1
38.2
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 1512.11
PubMed score by year
PubTator Score 1341.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title