Tchem RNASE2 Non-secretory ribonuclease

Protein Summary

Description

This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities. The protein encoded by this gene is a non-secretory ribonuclease that belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein antimicrobial activity against viruses. [provided by RefSeq, Oct 2014]

Uniprot Accession IDs

• P10153
• Q52M39
• Q9H2B7
• Q9UCG7

Gene Name

• RNASE2

Ensembl ID

• ENST00000304625
• ENSP00000303276
• ENSG00000169385

Symbol

• EDN
• RNS2
• EDN
• RAF3
• RNS2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.75
cell type or tissue	0.7
gene perturbation	0.65
cell line	0.64
tissue	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 481.05   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 157   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 481.05   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0