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Tbio
RMND5B
E3 ubiquitin-protein transferase RMND5B

Protein Summary
Description
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). Catalytic activity of the complex is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313386
  • ENSP00000320623
  • ENSG00000145916
  • ENST00000515098
  • ENSP00000420875

Symbol
  • GID2
  • GID2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
protein domain
0.85
transcription factor binding site profile
0.85
PubMedID
0.76
disease perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.52   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.52   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
BMP1
Tchem
Novelty:  0.00299518
p_int:  0.999998709
p_ni:  0.000001261
p_wrong:  3e-8
Score:  0.181
Data Source:  BioPlex,STRINGDB
MRPL4
Tdark
Novelty:  0.27290276
p_int:  0.999992669
p_ni:  0.000007309
p_wrong:  2.3e-8
Score:  0.162
Data Source:  BioPlex,STRINGDB
PIGT
Tbio
Family:  Enzyme
Novelty:  0.02539879
p_int:  0.999868117
p_ni:  0.000057518
p_wrong:  0.000074365
Score:  0.232
Data Source:  BioPlex,STRINGDB
TDGF1
Tbio
Novelty:  0.00527099
p_int:  0.999755921
p_ni:  0.00010337
p_wrong:  0.000140709
Score:  0.2
Data Source:  BioPlex,STRINGDB
GCG
Tchem
Novelty:  0.00004879
p_int:  0.998916546
p_ni:  5.86e-7
p_wrong:  0.001082868
Data Source:  BioPlex
PRG3
Tbio
Novelty:  0.09431986
p_int:  0.91581586
p_ni:  0.000035148
p_wrong:  0.084148993
Score:  0.177
Data Source:  BioPlex,STRINGDB
MAEA
Tbio
Novelty:  0.00833813
Score:  0.935
Data Source:  STRINGDB
GID8
Tbio
Novelty:  0.21243963
Score:  0.904
Data Source:  STRINGDB
WDR26
Tbio
Novelty:  0.04140166
Score:  0.895
Data Source:  STRINGDB
ARMC8
Tbio
Novelty:  0.06820746
Score:  0.849
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
2
2
83.9
reticulocyte measurement
2
1
2
73.7
reticulocyte count
1
1
1
70
platelet count
2
2
2
58.2
mean platelet volume
2
1
2
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
83.9
reticulocyte measurement
2
73.7
reticulocyte count
1
70
platelet count
2
58.2
mean platelet volume
2
36.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
required for meiotic nuclear division 5 homolog B
VGNC:4148
462317
Macaque
required for meiotic nuclear division 5 homolog B
701840
Mouse
MGI:1913339
66089
Rat
RGD:9131446
103689927
Dog
required for meiotic nuclear division 5 homolog B
VGNC:45611
474643
Species
Name
OMA
EggNOG
Inparanoid
Chimp
required for meiotic nuclear division 5 homolog B
Macaque
required for meiotic nuclear division 5 homolog B
Mouse
Rat
Dog
required for meiotic nuclear division 5 homolog B
Publication Statistics
PubMed Score 11.52
PubMed score by year
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Related Publications
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PMID
Year
Title