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Tbio
RMND5A
E3 ubiquitin-protein transferase RMND5A

Protein Summary
Description
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). Catalytic activity of the complex is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283632
  • ENSP00000283632
  • ENSG00000153561

Symbol
  • CTLH
  • GID2
  • RMD5
  • GID2A
  • p44CTLH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor perturbation
0.94
histone modification site profile
0.89
protein domain
0.85
disease perturbation
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.65   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 175   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.65   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (82)
ZMYND19
Tdark
Novelty:  0.3590069
p_int:  0.999941131
p_ni:  0.000058868
Score:  0.68
Data Source:  BioPlex,STRINGDB
RANBP10
Tbio
Novelty:  0.10818049
p_int:  0.99990264
p_ni:  0.00009736
Score:  0.968
Data Source:  BioPlex,STRINGDB
GCG
Tchem
Novelty:  0.00004879
p_int:  0.999515145
p_ni:  0.000484855
Data Source:  BioPlex
WDR26
Tbio
Novelty:  0.04140166
p_int:  0.999405391
p_ni:  0.000594609
Score:  0.984
Data Source:  BioPlex,STRINGDB
MKLN1
Tbio
Novelty:  0.05014385
p_int:  0.999375063
p_ni:  0.000624937
Score:  0.928
Data Source:  BioPlex,STRINGDB
GID4
Tbio
Novelty:  0.05252674
p_int:  0.999111161
p_ni:  0.000888839
Score:  0.971
Data Source:  BioPlex,STRINGDB
ARMC8
Tbio
Novelty:  0.06820746
p_int:  0.997470001
p_ni:  0.002529999
Score:  0.964
Data Source:  BioPlex,STRINGDB
MAEA
Tbio
Novelty:  0.00833813
p_int:  0.996334469
p_ni:  0.003665531
Score:  0.986
Data Source:  BioPlex,STRINGDB
HTRA2
Tbio
Family:  Enzyme
Novelty:  0.00343249
p_int:  0.995000125
p_ni:  0.004999875
Score:  0.543
Data Source:  BioPlex,STRINGDB
PRG3
Tbio
Novelty:  0.09431986
p_int:  0.992929862
p_ni:  0.007070138
Score:  0.802
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
4
7
92.7
reticulocyte measurement
3
1
3
79.5
mean corpuscular hemoglobin concentration
1
1
1
78.9
eosinophil count
1
1
1
64.4
eosinophil percentage of leukocytes
1
1
1
61.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
92.7
reticulocyte measurement
3
79.5
mean corpuscular hemoglobin concentration
1
78.9
eosinophil count
1
64.4
eosinophil percentage of leukocytes
1
61.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
required for meiotic nuclear division 5 homolog A
698206
Mouse
MGI:1915727
68477
Rat
RGD:1309766
312439
Dog
required for meiotic nuclear division 5 homolog A
VGNC:45610
475760
Horse
required for meiotic nuclear division 5 homolog A
VGNC:22414
100066793
Species
Name
OMA
EggNOG
Inparanoid
Macaque
required for meiotic nuclear division 5 homolog A
Mouse
Rat
Dog
required for meiotic nuclear division 5 homolog A
Horse
required for meiotic nuclear division 5 homolog A
Publication Statistics
PubMed Score 58.65
PubMed score by year
PubTator Score 9.24
PubTator score by year
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Related Publications
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PMID
Year
Title