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Tbio
RMC1
Regulator of MON1-CCZ1 complex

Protein Summary
Description
Componement of the CCZ1-MON1 RAB7A guanine exchange factor (GEF). Acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization (PubMed:29038162). This gene encodes a colon cancer associated protein. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269221
  • ENSP00000269221
  • ENSG00000141452

Symbol
  • C18orf8
  • MIC1
  • WDR98
  • MIC1
  • Mic-1
  • WDR98
  • C18orf8
  • HsT2591
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.43   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.43   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
SP6
Tbio
Family:  TF
Novelty:  0.00201789
p_int:  0.99999998
p_ni:  2e-8
p_wrong:  1e-9
Score:  0.29
Data Source:  BioPlex,STRINGDB
TNFSF10
Tchem
Novelty:  0.00096612
p_int:  0.999999887
p_ni:  1.11e-7
p_wrong:  2e-9
Data Source:  BioPlex
RNF181
Tbio
Family:  Enzyme
Novelty:  0.27482636
p_int:  0.999999668
p_ni:  3.32e-7
Data Source:  BioPlex
PCMT1
Tbio
Family:  Enzyme
Novelty:  0.01414946
p_int:  0.999997337
p_ni:  0.000002649
p_wrong:  1.5e-8
Score:  0.212
Data Source:  BioPlex,STRINGDB
NEFL
Tbio
Novelty:  0.00049255
p_int:  0.987325968
p_ni:  0.000282655
p_wrong:  0.012391377
Score:  0.237
Data Source:  BioPlex,STRINGDB
CCZ1B
Tdark
Novelty:  0.09724624
Score:  0.936
Data Source:  STRINGDB
CCZ1
Tbio
Novelty:  0.09830652
Score:  0.936
Data Source:  STRINGDB
MON1B
Tbio
Novelty:  0.13486379
Score:  0.911
Data Source:  STRINGDB
XPR1
Tbio
Novelty:  0.00735578
Score:  0.908
Data Source:  STRINGDB
MON1A
Tbio
Novelty:  0.04537045
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (37)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
3
9
95.8
body mass index
8
5
10
95.8
reticulocyte measurement
3
2
6
93
neutrophil count
3
2
3
81
high density lipoprotein cholesterol measurement
2
2
2
80.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
9
95.8
body mass index
10
95.8
reticulocyte measurement
6
93
neutrophil count
3
81
high density lipoprotein cholesterol measurement
2
80.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
regulator of MON1-CCZ1
VGNC:5146
100611481
Macaque
WD repeat domain 98
700967
Mouse
MGI:1916528
76482
Rat
RGD:1311805
291784
Dog
regulator of MON1-CCZ1
VGNC:49596
606951
Species
Name
OMA
EggNOG
Inparanoid
Chimp
regulator of MON1-CCZ1
Macaque
WD repeat domain 98
Mouse
Rat
Dog
regulator of MON1-CCZ1
Publication Statistics
PubMed Score 34.43
PubMed score by year
PubTator Score 8.00
PubTator score by year
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Related Publications
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PMID
Year
Title