Protein Summary
May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142). This gene encodes a member of the relaxin family of insulin-like hormones that is expressed predominantly in the brain and plays a role in physiological processes such as stress, memory and appetite regulation. The encoded protein is a precursor that is proteolytically processed to generate a heterodimeric mature form consisting A and B chains interlinked by disulfide bonds. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]
- ENST00000431365
- ENSP00000397415
- ENSG00000171136
- INSL7
- RXN3
- ZINS4
- H3
- RXN3
- ZINS4
- insl7
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue | 0.62 | ||
pathway | 0.52 | ||
PubMedID | 0.46 | ||
cell line | 0.45 | ||
biological term | 0.44 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 115.24 (req: < 5)
Gene RIFs: 26 (req: <= 3)
Antibodies: 140 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 115.24 (req: >= 5)
Gene RIFs: 26 (req: > 3)
Antibodies: 140 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (341)
Nearest Tclin Targets
Pathways (11)
Reactome (9)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | G alpha (s) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (i) signalling events | ||||
G alpha (s) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Viral Interactions (0)
Gene Ontology Terms (4)
Functions (2)
Components (1)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
neutrophil percentage of leukocytes | 1 | 1 | 1 | 62.1 | |||||
lymphocyte count | 1 | 1 | 1 | 58.4 | |||||
reticulocyte count | 2 | 2 | 2 | 56.6 | |||||
lymphocyte percentage of leukocytes | 1 | 1 | 1 | 53.7 | |||||
sex hormone-binding globulin measurement | 2 | 1 | 2 | 40.4 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
neutrophil percentage of leukocytes | 1 | 62.1 | |||||
lymphocyte count | 1 | 58.4 | |||||
reticulocyte count | 2 | 56.6 | |||||
lymphocyte percentage of leukocytes | 1 | 53.7 | |||||
sex hormone-binding globulin measurement | 2 | 40.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | relaxin 3 | VGNC:2265 | 747967 | |||||
Mouse | MGI:2158015 | 212108 | ||||||
Rat | RGD:628745 | 266997 | ||||||
Horse | relaxin 3 | VGNC:22409 | 100630151 | |||||
Cow | relaxin 3 | VGNC:33991 | 100300034 | |||||
Publication Statistics
PubMed Score 115.24
PubMed score by year
PubTator Score 63.47
PubTator score by year
Related Publications
Text Mined References (34)
GeneRif Annotations (26)
Items per page:
0 of 0
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