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Tbio
RLN3
Relaxin-3

Protein Summary
Description
May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142). This gene encodes a member of the relaxin family of insulin-like hormones that is expressed predominantly in the brain and plays a role in physiological processes such as stress, memory and appetite regulation. The encoded protein is a precursor that is proteolytically processed to generate a heterodimeric mature form consisting A and B chains interlinked by disulfide bonds. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000431365
  • ENSP00000397415
  • ENSG00000171136

Symbol
  • INSL7
  • RXN3
  • ZINS4
  • H3
  • RXN3
  • ZINS4
  • insl7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.62
pathway
0.52
PubMedID
0.46
cell line
0.45
biological term
0.44


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.24   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.24   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (341)
INSL5
Tbio
Novelty:  0.04351334
Score:  0.998
Data Source:  STRINGDB
RXFP3
Tchem
Family:  GPCR
Novelty:  0.01844783
Score:  0.996
Data Source:  Reactome,STRINGDB
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
Score:  0.993
Data Source:  Reactome,STRINGDB
RXFP4
Tchem
Family:  GPCR
Novelty:  0.05054041
Score:  0.993
Data Source:  Reactome,STRINGDB
RXFP2
Tbio
Family:  GPCR
Novelty:  0.00932189
Score:  0.982
Data Source:  STRINGDB
RLN2
Tbio
Novelty:  0.00743118
Score:  0.98
Data Source:  STRINGDB
INSL3
Tbio
Novelty:  0.00374656
Score:  0.978
Data Source:  STRINGDB
CRH
Tbio
Novelty:  0.000147
Score:  0.947
Data Source:  STRINGDB
CRHR1
Tclin
Family:  GPCR
Novelty:  0.00101773
Score:  0.946
Data Source:  STRINGDB
SSTR5
Tclin
Family:  GPCR
Novelty:  0.00568309
Score:  0.946
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
1
1
62.1
lymphocyte count
1
1
1
58.4
reticulocyte count
2
2
2
56.6
lymphocyte percentage of leukocytes
1
1
1
53.7
sex hormone-binding globulin measurement
2
1
2
40.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
62.1
lymphocyte count
1
58.4
reticulocyte count
2
56.6
lymphocyte percentage of leukocytes
1
53.7
sex hormone-binding globulin measurement
2
40.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
relaxin 3
VGNC:2265
747967
Mouse
MGI:2158015
212108
Rat
RGD:628745
266997
Horse
relaxin 3
VGNC:22409
100630151
Cow
relaxin 3
VGNC:33991
100300034
Species
Name
OMA
EggNOG
Inparanoid
Chimp
relaxin 3
Mouse
Rat
Horse
relaxin 3
Cow
relaxin 3
Publication Statistics
PubMed Score 115.24
PubMed score by year
PubTator Score 63.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title