Tbio RLN3 Relaxin-3

Protein Summary

Description

May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142). This gene encodes a member of the relaxin family of insulin-like hormones that is expressed predominantly in the brain and plays a role in physiological processes such as stress, memory and appetite regulation. The encoded protein is a precursor that is proteolytically processed to generate a heterodimeric mature form consisting A and B chains interlinked by disulfide bonds. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]

Uniprot Accession IDs

• Q8WXF3
• Q6UXW5

Gene Name

• RLN3

Ensembl ID

• ENST00000431365
• ENSP00000397415
• ENSG00000171136

Symbol

• INSL7
• RXN3
• ZINS4
• H3
• RXN3
• ZINS4
• insl7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.62
pathway	0.52
PubMedID	0.46
cell line	0.45
biological term	0.44

Protein Classes

DTO Classes

Relaxin-3 Receptor 2 / Relaxin-3 Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.28   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 140   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.28   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0