Protein Summary
Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix. Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The protein encoded by this gene is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. [provided by RefSeq, Jan 2013]
- ENST00000223862
- ENSP00000223862
- ENSG00000107018
- H1
- H1RLX
- RLXH1
- bA12D24.3.1
- bA12D24.3.2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.6 | ||
gene perturbation | 0.59 | ||
protein domain | 0.58 | ||
phenotype | 0.57 | ||
cell line | 0.51 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.53 (req: < 5)
Gene RIFs: 40 (req: <= 3)
Antibodies: 259 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.53 (req: >= 5)
Gene RIFs: 40 (req: > 3)
Antibodies: 259 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (102)
RLN2
Novelty: 0.00743118
p_int: 0.999999993
p_ni: 3e-9
p_wrong: 4e-9
Score: 0.845
Data Source: BioPlex,STRINGDB
GLB1L
Family: Enzyme
Novelty: 0.43027328
p_int: 0.99993175
p_ni: 0.000068229
p_wrong: 2.1e-8
Data Source: BioPlex
LARGE1
Family: Enzyme
Novelty: 0.02518701
p_int: 0.999860821
p_ni: 0.000137902
p_wrong: 0.000001278
Data Source: BioPlex
VWDE
Novelty: 0.37298162
p_int: 0.999809743
p_ni: 0.000189468
p_wrong: 7.89e-7
Data Source: BioPlex
CTSF
Family: Enzyme
Novelty: 0.01359417
p_int: 0.999726746
p_ni: 0.000265819
p_wrong: 0.000007435
Data Source: BioPlex
SEMA6A
Novelty: 0.00624456
p_int: 0.999512341
p_ni: 0.000487651
p_wrong: 8e-9
Data Source: BioPlex
NAAA
Family: Enzyme
Novelty: 0.00368876
p_int: 0.99941834
p_ni: 0.000179682
p_wrong: 0.000401978
Data Source: BioPlex
PDGFC
Novelty: 0.00642236
p_int: 0.999322546
p_ni: 0.000483512
p_wrong: 0.000193942
Data Source: BioPlex
LMLN
Family: Enzyme
Novelty: 0.00289803
p_int: 0.999277394
p_ni: 0.000619623
p_wrong: 0.000102983
Data Source: BioPlex
EOGT
Family: Enzyme
Novelty: 0.08290891
p_int: 0.999011534
p_ni: 0.000988464
p_wrong: 1e-9
Data Source: BioPlex
Nearest Tclin Targets
Pathways (11)
Reactome (7)
KEGG (2)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Attenuation phase | ||||
Reactome | Cellular response to heat stress | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | HSF1 activation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Attenuation phase | ||||
Cellular response to heat stress | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
HSF1 activation | ||||
Viral Interactions (0)
Gene Ontology Terms (4)
Functions (1)
Components (1)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
Thyroid preparation use measurement | 1 | 1 | 1 | 36.5 | |||||
autoimmune thyroid disease | 1 | 1 | 0 | 1.1 | 13.1 | ||||
1 | 1 | 0 | 1.4 | 4.1 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
Thyroid preparation use measurement | 1 | 36.5 | |||||
autoimmune thyroid disease | 0 | 1.1 | 13.1 | ||||
0 | 1.4 | 4.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:97931 | 19773 | ||||||
Rat | RGD:3579 | 25616 | ||||||
Dog | relaxin 2 | 403742 | ||||||
Horse | eprorelaxin | 100033823 | ||||||
Pig | relaxin 2 | 396891 | ||||||
Publication Statistics
PubMed Score 21.53
PubMed score by year
PubTator Score 34.20
PubTator score by year
Related Publications
Text Mined References (66)
GeneRif Annotations (40)
Items per page:
0 of 0
PMID | Year | Title |
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