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Tbio
RLN1
Prorelaxin H1

Protein Summary
Description
Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix. Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The protein encoded by this gene is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223862
  • ENSP00000223862
  • ENSG00000107018

Symbol
  • H1
  • H1RLX
  • RLXH1
  • bA12D24.3.1
  • bA12D24.3.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.6
gene perturbation
0.59
protein domain
0.58
phenotype
0.57
cell line
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.53   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 259   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.53   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 259   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (102)
RLN2
Tbio
Novelty:  0.00743118
p_int:  0.999999993
p_ni:  3e-9
p_wrong:  4e-9
Score:  0.845
Data Source:  BioPlex,STRINGDB
GLB1L
Tdark
Family:  Enzyme
Novelty:  0.43027328
p_int:  0.99993175
p_ni:  0.000068229
p_wrong:  2.1e-8
Data Source:  BioPlex
LARGE1
Tbio
Family:  Enzyme
Novelty:  0.02518701
p_int:  0.999860821
p_ni:  0.000137902
p_wrong:  0.000001278
Data Source:  BioPlex
VWDE
Tdark
Novelty:  0.37298162
p_int:  0.999809743
p_ni:  0.000189468
p_wrong:  7.89e-7
Data Source:  BioPlex
CTSF
Tchem
Family:  Enzyme
Novelty:  0.01359417
p_int:  0.999726746
p_ni:  0.000265819
p_wrong:  0.000007435
Data Source:  BioPlex
SEMA6A
Tbio
Novelty:  0.00624456
p_int:  0.999512341
p_ni:  0.000487651
p_wrong:  8e-9
Data Source:  BioPlex
NAAA
Tchem
Family:  Enzyme
Novelty:  0.00368876
p_int:  0.99941834
p_ni:  0.000179682
p_wrong:  0.000401978
Data Source:  BioPlex
PDGFC
Tbio
Novelty:  0.00642236
p_int:  0.999322546
p_ni:  0.000483512
p_wrong:  0.000193942
Data Source:  BioPlex
LMLN
Tdark
Family:  Enzyme
Novelty:  0.00289803
p_int:  0.999277394
p_ni:  0.000619623
p_wrong:  0.000102983
Data Source:  BioPlex
EOGT
Tbio
Family:  Enzyme
Novelty:  0.08290891
p_int:  0.999011534
p_ni:  0.000988464
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Attenuation phase (R-HSA-3371568)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Attenuation phase
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
HSF1 activation
Name
Explore in Pharos
Explore in Source
Attenuation phase
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
HSF1 activation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Thyroid preparation use measurement
1
1
1
36.5
autoimmune thyroid disease
1
1
0
1.1
13.1
1
1
0
1.4
4.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Thyroid preparation use measurement
1
36.5
autoimmune thyroid disease
0
1.1
13.1
0
1.4
4.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:97931
19773
Rat
RGD:3579
25616
Dog
relaxin 2
403742
Horse
eprorelaxin
100033823
Pig
relaxin 2
396891
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
relaxin 2
Horse
eprorelaxin
Pig
relaxin 2
Publication Statistics
PubMed Score 21.53
PubMed score by year
PubTator Score 34.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title