You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RIPPLY2
Protein ripply2

Protein Summary
Description
Plays a role in somitogenesis. Required for somite segregation and establishment of rostrocaudal polarity in somites (By similarity). This gene encodes a nuclear protein that belongs to a novel family of proteins required for vertebrate somitogenesis. Members of this family have a tetrapeptide WRPW motif that is required for interaction with the transcriptional repressor Groucho and a carboxy-terminal Ripply homology domain/Bowline-DSCR-Ledgerline conserved region required for transcriptional repression. Null mutant mice die soon after birth and display defects in axial skeleton segmentation due to defective somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369687
  • ENSP00000358701
  • ENSG00000203877
  • ENST00000369689
  • ENSP00000358703

Symbol
  • C6orf159
  • SCDO6
  • C6orf159
  • dJ237I15.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
histone modification site profile
0.62
cell type or tissue
0.61
tissue
0.48
cell line
0.45


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.9   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.9   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
TLE4
Tbio
Novelty:  0.02094922
p_int:  0.999999968
p_ni:  3.2e-8
Score:  0.734
Data Source:  BioPlex,STRINGDB
TLE2
Tbio
Novelty:  0.03922169
p_int:  0.999999895
p_ni:  1.04e-7
p_wrong:  1e-9
Score:  0.273
Data Source:  BioPlex,STRINGDB
AES
Tbio
Novelty:  0.00818499
p_int:  0.999999839
p_ni:  1.61e-7
Score:  0.694
Data Source:  BioPlex,STRINGDB
TLE3
Tbio
Novelty:  0.02641884
p_int:  0.999999284
p_ni:  7.16e-7
Score:  0.319
Data Source:  BioPlex,STRINGDB
TLE1
Tbio
Novelty:  0.00594261
p_int:  0.999995914
p_ni:  0.000004086
Score:  0.317
Data Source:  BioPlex,STRINGDB
TRIP6
Tbio
Novelty:  0.02183202
p_int:  0.997676737
p_ni:  0.002323263
Data Source:  BioPlex
USP4
Tchem
Family:  Enzyme
Novelty:  0.01101075
p_int:  0.995560127
p_ni:  0.004201039
p_wrong:  0.000238834
Data Source:  BioPlex
RBM23
Tbio
Novelty:  0.03769792
p_int:  0.9875957
p_ni:  0.012404297
p_wrong:  3e-9
Score:  0.185
Data Source:  BioPlex,STRINGDB
FERMT2
Tbio
Novelty:  0.01020276
p_int:  0.94639277
p_ni:  0.052851949
p_wrong:  0.000755281
Score:  0.188
Data Source:  BioPlex,STRINGDB
EXOG
Tbio
Family:  Enzyme
Novelty:  0.03588463
p_int:  0.916891667
p_ni:  0.083108243
p_wrong:  9e-8
Score:  0.167
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (25)
Find Similar Targets
Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Gene regulatory network modelling somitogenesis
WikiPathways
Gene regulatory network modelling somitogenesis
WikiPathways
Gene regulatory network modelling somitogenesis
WikiPathways
Gene regulatory network modelling somitogenesis
WikiPathways
Gene regulatory network modelling somitogenesis
Name
Explore in Pharos
Explore in Source
Gene regulatory network modelling somitogenesis
Gene regulatory network modelling somitogenesis
Gene regulatory network modelling somitogenesis
Gene regulatory network modelling somitogenesis
Gene regulatory network modelling somitogenesis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical thickness
1
1
0
9.4
63.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical thickness
0
9.4
63.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ripply transcriptional repressor 2
VGNC:11211
100608785
Macaque
ripply transcriptional repressor 2 [Source:HGNC Symbol;Acc:HGNC:21390]
Mouse
MGI:2685968
382089
Rat
RGD:1308746
363111
Dog
ripply transcriptional repressor 2 [Source:HGNC Symbol;Acc:HGNC:21390]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ripply transcriptional repressor 2
Macaque
ripply transcriptional repressor 2 [Source:HGNC Symbol;Acc:HGNC:21390]
Mouse
Rat
Dog
ripply transcriptional repressor 2 [Source:HGNC Symbol;Acc:HGNC:21390]
Publication Statistics
PubMed Score 5.90
PubMed score by year
PubTator Score 3.03
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title