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Tdark
RIPPLY1
Protein ripply1

Protein Summary
Description
Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites (By similarity). This gene encodes a protein similar to a zebrafish protein which acts as a transcriptional repressor in and is required for somite segmentation in zebrafish embryos (PMID: 16326386). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276173
  • ENSP00000276173
  • ENSG00000147223
  • ENST00000411805
  • ENSP00000400539
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.62
PubMedID
0.55
cellular component
0.43
microRNA
0.36
cell line
0.35


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.22   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 12   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.22   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 12   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (15)
TLE4
Tbio
Novelty:  0.02094922
p_int:  0.999999995
p_ni:  5e-9
Score:  0.757
Data Source:  BioPlex,STRINGDB
TLE2
Tbio
Novelty:  0.03922169
p_int:  0.999999978
p_ni:  1.5e-8
p_wrong:  7e-9
Score:  0.364
Data Source:  BioPlex,STRINGDB
TLE1
Tbio
Novelty:  0.00594261
p_int:  0.999999646
p_ni:  3.54e-7
Score:  0.289
Data Source:  BioPlex,STRINGDB
TLE3
Tbio
Novelty:  0.02641884
p_int:  0.999996988
p_ni:  0.000003012
Score:  0.219
Data Source:  BioPlex,STRINGDB
AES
Tbio
Novelty:  0.00818499
p_int:  0.999850986
p_ni:  0.000147421
p_wrong:  0.000001593
Score:  0.831
Data Source:  BioPlex,STRINGDB
CHMP6
Tbio
Novelty:  0.02931
p_int:  0.917266662
p_ni:  0.082626915
p_wrong:  0.000106423
Score:  0.379
Data Source:  BioPlex,STRINGDB
MESP2
Tbio
Family:  TF
Novelty:  0.02601024
Score:  0.705
Data Source:  STRINGDB
TBX6
Tbio
Family:  TF
Novelty:  0.01060902
Score:  0.66
Data Source:  STRINGDB
MORC4
Tbio
Novelty:  0.17017364
Score:  0.588
Data Source:  STRINGDB
MESP1
Tbio
Family:  TF
Novelty:  0.03965223
Score:  0.565
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
7
0
2.2
97.4
2
1
1
1.4
62.3
type 2 diabetes mellitus
1
1
1
5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.2
97.4
1
1.4
62.3
type 2 diabetes mellitus
1
5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ripply transcriptional repressor 1
VGNC:1207
738806
Macaque
ripply transcriptional repressor 1 [Source:HGNC Symbol;Acc:HGNC:25117]
Mouse
MGI:3614797
622473
Rat
RGD:1588264
680702
Dog
ripply transcriptional repressor 1
VGNC:45599
610288
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ripply transcriptional repressor 1
Macaque
ripply transcriptional repressor 1 [Source:HGNC Symbol;Acc:HGNC:25117]
Mouse
Rat
Dog
ripply transcriptional repressor 1
Publication Statistics
PubMed Score 10.22
PubMed score by year
PubTator Score 0.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title