You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RIPOR2
Rho family-interacting cell polarization regulator 2

Protein Summary
Description
Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (PubMed:17150207, PubMed:24687993, PubMed:23241886, PubMed:24958875, PubMed:25588844, PubMed:27556504). Inhibits chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (PubMed:23241886). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion (By similarity). Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear (By similarity). Plays a role for maintaining the structural organization of the basal domain of stereocilia (By similarity). Involved in mechanosensory hair cell function (By similarity). Required for normal hearing (PubMed:24958875). Isoform 2: Acts as an inhibitor of the small GTPase RHOA (PubMed:25588844). Plays a role in fetal mononuclear myoblast differentiation by promot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259698
  • ENSP00000259698
  • ENSG00000111913
  • ENST00000378023
  • ENSP00000367262
  • ENST00000613507
  • ENSP00000482957
  • ENST00000643623
  • ENSP00000495245
  • ENST00000644621
  • ENSP00000495914
  • ENST00000644685
  • ENSP00000496721

Symbol
  • C6orf32
  • DIFF48
  • FAM65B
  • KIAA0386
  • PL48
  • PL48
  • DIFF40
  • DIFF48
  • FAM65B
  • MYONAP
  • C6orf32
  • DFNB104
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.24   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.24   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.786
Data Source:  STRINGDB
CANT1
Tbio
Family:  Enzyme
Novelty:  0.02640333
Score:  0.682
Data Source:  STRINGDB
IGFN1
Tbio
Novelty:  0.23407022
Score:  0.665
Data Source:  STRINGDB
MSS51
Tbio
Novelty:  0.06388791
Score:  0.654
Data Source:  STRINGDB
MYBPH
Tbio
Novelty:  0.00247863
Score:  0.644
Data Source:  STRINGDB
MYOG
Tbio
Family:  TF
Novelty:  0.00074867
Score:  0.623
Data Source:  STRINGDB
C6orf62
Tdark
Novelty:  1.21509188
Score:  0.586
Data Source:  STRINGDB
ACTC1
Tbio
Novelty:  0.00188036
Score:  0.573
Data Source:  STRINGDB
ST8SIA3
Tbio
Family:  Enzyme
Novelty:  0.05984127
Score:  0.562
Data Source:  STRINGDB
KIAA0319
Tbio
Novelty:  0.01425914
Score:  0.543
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
2
3
4
83.5
alkaline phosphatase measurement
1
1
1
75.6
lymphocyte percentage of leukocytes
2
1
2
74.1
lymphocyte count
2
1
2
71
neutrophil percentage of leukocytes
2
1
2
70.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
4
83.5
alkaline phosphatase measurement
1
75.6
lymphocyte percentage of leukocytes
2
74.1
lymphocyte count
2
71
neutrophil percentage of leukocytes
2
70.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RHO family interacting cell polarization regulator 2
VGNC:2824
462479
Macaque
RHO family interacting cell polarization regulator 2
715354
Mouse
MGI:2444879
193385
Rat
RGD:1306939
306934
Dog
RHO family interacting cell polarization regulator 2
VGNC:45597
488247
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RHO family interacting cell polarization regulator 2
Macaque
RHO family interacting cell polarization regulator 2
Mouse
Rat
Dog
RHO family interacting cell polarization regulator 2
Publication Statistics
PubMed Score 21.24
PubMed score by year
PubTator Score 11.01
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title