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Tchem
RIPK4
Receptor-interacting serine/threonine-protein kinase 4

Protein Summary
Description
Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation. The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332512
  • ENSP00000332454
  • ENSG00000183421
  • ENST00000352483
  • ENSP00000330161

Symbol
  • ANKRD3
  • DIK
  • DIK
  • PKK
  • PPS2
  • RIP4
  • ANKK2
  • NKRD3
  • ANKRD3
  • CHANDS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.78
virus perturbation
0.68
gene perturbation
0.67
transcription factor binding site profile
0.67
transcription factor perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.76   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 284   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.76   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0