Tchem RIPK3 Receptor-interacting serine/threonine-protein kinase 3

Protein Summary

Description

Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y572
• B4DJL9
• C4AM87
• Q5J795
• Q5J796
• Q6P5Y1

Gene Name

• RIPK3

Ensembl ID

• ENST00000216274
• ENSP00000216274
• ENSG00000129465
• ENST00000554756
• ENSP00000452328
• ENST00000643393
• ENSP00000495915
• ENSG00000285379
• ENST00000646516
• ENSP00000495490

Symbol

• RIP3
• RIP3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
hub protein	0.99
molecular function	0.99
virus perturbation	0.85
protein domain	0.73

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tkl Group / Ripk Family / Receptor-interacting Serine/threonine-protein Kinase 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 496.37   (req: < 5)

Gene RIFs: 150   (req: <= 3)

Antibodies: 768   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 496.37   (req: >= 5)

Gene RIFs: 150   (req: > 3)

Antibodies: 768   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2